ArticleJournal of biomedical optics2016
Rapid, noninvasive quantitation of skin disease in systemic sclerosis using optical coherence elastography.
Article in Journal of biomedical optics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 40 citations in OpenAlex.
- Noninvasive quantitative assessment of oral submucosal fibrosisJournal of biomedical optics · 2025Article
- ALK5 inhibitor impact on bleomycin-induced systemic sclerosis mouse model via multifunctional optical coherence tomography.APL bioengineering · 2025Article
- In vivo quantification of viscoelastic property alterations in oral submucous fibrosis using optical coherence elastography.Biomedical optics express · 2025Article
- Assessment of skin fibrosis in a murine model of systemic sclerosis with multifunctional optical coherence tomography.Journal of biomedical optics · 2025Article
- Dual optical elastography detectsJournal of biomedical optics · 2024Article
- In vivo measurement of the biomechanical properties of human skin with motion-corrected Brillouin microscopy.Biomedical optics express · 2024Article
- VP-net: an end-to-end deep learning network for elastic wave velocity prediction in human skinFrontiers in bioengineering and biotechnology · 2024Article
- Spatial frequency domain imaging for the assessment of scleroderma skin involvement.Biomedical optics express · 2023Article
- Wave-based optical coherence elastography: The 10-year perspective.Progress in biomedical engineering (Bristol, England) · 2022Article
- 1.7-Micron Optical Coherence Tomography Angiography for Characterization of Skin Lesions-A Feasibility Study.IEEE transactions on medical imaging · 2021Article
- Deep Learning Classification of Systemic Sclerosis Skin Using the MobileNetV2 Model.IEEE open journal of engineering in medicine and biology · 2021Article
- Translational optical coherence elastography for assessment of systemic sclerosis.Journal of biophotonics · 2019Article
- Quantifying the effects of hydration on corneal stiffness with noncontact optical coherence elastography.Journal of cataract and refractive surgery · 2018Article
- Ultra-fast line-field low coherence holographic elastography using spatial phase shifting.Biomedical optics express · 2017Article
- Optical coherence elastography - OCT at work in tissue biomechanics [Invited].Biomedical optics express · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Systemic sclerosis (SSc) is a connective tissue disease that results in excessive accumulation of collagen in the skin and internal organs. Overall, SSc has a rare morbidity (276 cases per million adults in the United States), but has a 10-year survival rate of 55%. Currently, the modified Rodnan skin score (mRSS) is assessed by palpation on 17 sites on the body. However, the mRSS assessed score is subjective and may be influenced by the experience of the rheumatologists. In addition, the inherent elasticity of skin may bias the mRSS assessment in the early stage of SSc, such as oedematous. Optical coherence elastography (OCE) is a rapidly emerging technique, which can assess mechanical contrast in tissues with micrometer spatial resolution. In this work, the OCE technique is applied to assess the mechanical properties of skin in both control and bleomycin (BLM) induced SSc-like disease noninvasively. Young’s modulus of the BLM-SSc skin was found be significantly higher than that of normal skin, in both the in vivo and in vitro studies (p<0.05 p<0.05 ). Thus, OCE is able to differentiate healthy and fibrotic skin using mechanical contrast. It is a promising new technology for quantifying skin involvement in SSc in a rapid, unbiased, and noninvasive manner.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.