Evidence map›Paper›PMID 27048738›Full record

ArticleDevelopment (Cambridge, England)2016

2- and 6-O-sulfated proteoglycans have distinct and complementary roles in cranial axon guidance and motor neuron migration.

Miguel Tillo, Camille Charoy, Quenten Schwarz, Charlotte H Maden, Kathryn Davidson, Alessandro Fantin, Christiana Ruhrberg

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Development (Cambridge, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.7field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Epithelial Heparan Sulfate PromotesProteoglycan research · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Deciphering functional glycosaminoglycan motifs in development.Current opinion in structural biology · 2018
    Review
  17. Review
  18. Review
  19. Review
  20. Diverse roles for glycosaminoglycans in neural patterning.Developmental dynamics : an official publication of the American Association of Anatomists · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Miguel TilloUCL Institute of Ophthalmology, University College London, 11-43 Bath Street, London EC1V 9EL, UK.ORCID 0000-0002-2024-1499
Camille CharoyUCL Institute of Ophthalmology, University College London, 11-43 Bath Street, London EC1V 9EL, UK.ORCID 0000-0003-1904-4612
Quenten SchwarzUCL Institute of Ophthalmology, University College London, 11-43 Bath Street, London EC1V 9EL, UK.ORCID 0000-0002-5958-4181
Charlotte H MadenUCL Institute of Ophthalmology, University College London, 11-43 Bath Street, London EC1V 9EL, UK.
Kathryn DavidsonUCL Institute of Ophthalmology, University College London, 11-43 Bath Street, London EC1V 9EL, UK.
Alessandro FantinUCL Institute of Ophthalmology, University College London, 11-43 Bath Street, London EC1V 9EL, UK.
Christiana RuhrbergUCL Institute of Ophthalmology, University College London, 11-43 Bath Street, London EC1V 9EL, UK Yale Cardiovascular Research Centre, Yale University, New Haven, CT 06511, USA c.ruhrberg@ucl.ac.uk.ORCID 0000-0002-3212-9381
University College London · GBCentre for Cancer Biology · AUYale University · US

Funding

Wellcome TrustWellcome Trust 089775/Z/09/ZWellcome Trust 092839/Z/10/Z
6 · The paper itself

Abstract

The correct migration and axon extension of neurons in the developing nervous system is essential for the appropriate wiring and function of neural networks. Here, we report that O-sulfotransferases, a class of enzymes that modify heparan sulfate proteoglycans (HSPGs), are essential to regulate neuronal migration and axon development. We show that the 6-O-sulfotransferases HS6ST1 and HS6ST2 are essential for cranial axon patterning, whilst the 2-O-sulfotransferase HS2ST (also known as HS2ST1) is important to regulate the migration of facial branchiomotor (FBM) neurons in the hindbrain. We have also investigated how HS2ST interacts with other signals in the hindbrain and show that fibroblast growth factor (FGF) signalling regulates FBM neuron migration in an HS2ST-dependent manner.

Indexed as

Axon GuidanceAnimalsCell MovementFibroblast Growth FactorsMice, Inbred C57BLMotor NeuronsProteoglycansSkullSulfatesSulfotransferasesTrigeminal GanglionVascular Endothelial Growth Factor AFibroblast Growth FactorsProteoglycansSulfatesSulfotransferasesVascular Endothelial Growth Factor AAxon guidanceFibroblast growth factor (FGF)Heparan sulfate proteoglycan (HSPG)Neuron migrationSulfotransferaseVascular endothelial growth factor (VEGF)

Identifiers

PMID27048738
PMCPMC4920156
OpenAlexW2320800717

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.