ArticleBMC surgery2016
28 day post-operative persisted hypercoagulability after surgery for benign diseases: a prospective cohort study.
Article in BMC surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Systematic review of venous thromboembolism risk categories derived from Caprini score.Journal of vascular surgery. Venous and lymphatic disorders · 2022Pooled it
- Trial
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- Spontaneous Contralateral Adrenal Hemorrhage during Periduodenal Abscess Drain Placement.Diagnostics (Basel, Switzerland) · 2024Article
- A comprehensive deep venous thrombosis prophylaxis regimen in isolated coronary artery bypass grafting.JTCVS open · 2024Article
- C-reactive protein, immunothrombosis and venous thromboembolism.Frontiers in immunology · 2022Review
- Major surgery leads to a proinflammatory phenotype: Differential gene expression following a laparotomy.Annals of medicine and surgery (2012) · 2021Article
- Safety of Inguinal Hernia Repair in the Elderly with Perioperative Continuation of Antithrombotic Therapy.Visceral medicine · 2021Article
- Comparison of postoperative plasma D-dimer levels between patients undergoing laparoscopic resection and conventional open resection for colorectal cancer.Asian journal of endoscopic surgery · 2020Article
- Incidence of Venous Thromboembolism Following Major Emergency Abdominal Surgery.World journal of surgery · 2020Article
- Venous thromboembolism in emergency general surgery patients: a single-centre retrospective cohort studyCanadian journal of surgery. Journal canadien de chirurgie · 2020Article
- [Rate of thrombosis and bleeding after urological surgery under standardized anticoagulation].Der Urologe. Ausg. A · 2020Article
- The Potential for Cancer Immunotherapy in Targeting Surgery-Induced Natural Killer Cell Dysfunction.Cancers · 2018Review
- Short-term recovery pattern of plasma fibrinogen after cardiac surgery: A prospective observational study.PloS one · 2018Observational
- Dysfunctional Natural Killer Cells in the Aftermath of Cancer Surgery.International journal of molecular sciences · 2017Review
- Testing of a risk-stratified patient decision aid to facilitate shared decision-making for extended postoperative thromboprophylaxis after major abdominal surgery for cancer.Canadian journal of surgery. Journal canadien de chirurgieArticle
- Risk factors for hypercoagulability after laparoscopic hepatic haemangioma resection.Journal of minimal access surgeryArticle
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSurgery for benign disease is associated with a low-risk of developing venous thromboembolism (VTE). Despite a relatively low incidence of postoperative VTE in patients after elective cholecystectomy and abdominal hernia repair there are data proving hypercoagulability in the early postoperative period. We focused on assessment of the systemic inflammatory response and coagulation status in these surgical patients after hospital discharge.
methodsProspectively, patients who underwent surgery for benign disease were included. Two hundred sixteen patients were enrolled - 90 patients in laparoscopic cholecystectomy (LC) group and 126 patients in hernia surgery (HS) group. Risk assessment of VTE according to the Caprini risk assessment model was performed in all patients. Prevalence of VTE in postoperative period was observed. Markers of systemic inflammatory response (IL-6, CRP, α-1-acid glycoprotein, transferrin) and coagulation markers (PLT, fibrinogen, prothrombin fragment F1 + 2 and D-dimer) were measured before surgery, on 7-10th postoperative day and on 28-30th postoperative day.
resultsClinically apparent deep vein thrombosis was diagnosed in only one patient - 0.46%. Statistically significant elevation of inflammatory markers IL-6, CRP and α-1-acid glycoprotein (p < 0.001; all) were proved in both groups of patients on 7-10th postoperative day. Statistically significant elevation of coagulation markers PLT, fibrinogen, prothrombin fragment F1 + 2 and D-dimer (p < 0.001; all) were proved in LC and HS groups on 7-10th postoperative day. No statistical difference was observed in IL-6, CRP and α-1-acid glycoprotein levels a month after surgery as compared with preoperative levels within each group. Statistically significant elevation of fibrinogen and prothrombin fragment F1 + 2 levels (p < 0.001; both) persisted on 28-30th postoperative day in both groups. Persisted elevation of D-dimer levels was proved only in HS group (p < 0.001), not in LC group (p = 0.138), a month after surgery.
conclusionsActivated systemic inflammatory response and hypercoagulable condition were verified in patients after laparoscopic cholecystectomy and hernia surgery after their hospital discharge. Hypercoagulability persisted even a month after surgery. Nevertheless, we observed very low prevalence of clinically apparent VTE in patients with in-hospital postoperative VTE prophylaxis.
trial registrationTrials of the Czech Ministry of Health No. RVO-VFN64165 and NT 13251-4 .
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