Evidence map›Paper›PMID 27048547›Full record

ReviewGenome medicine2016

Mood by microbe: towards clinical translation.

Timothy G Dinan, John F Cryan

2 registry-linked trialsAbstract readReview
In one paragraph

Review in Genome medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 52 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04046822 phase4unknown statusstarted 2019, after this paper: background citation

Could Gut Microbiome Contribute to the Therapeutic Effect of Liraglutide 3.0 mg? A Randomized Double Blind Placebo Controlled Trial

Ran2019Enrolled70Registered outcomes21Posted comparisons0ConditionsMicrobiome, Obesity, Weight LossArmsLiraglutide 6 MG/ML [Saxenda], Placebo
Open the trial in the graph
NCT03494725 nacompletednot on this mapstarted 2018, after this paper: background citation

Proof-of-Concept "Stress & Anxiety Dampening Effects of Lpc-37"

TypeinterventionalSponsorDaacroRan2018 to 2018Enrolled120ConditionsHealthy, Stress, PsychologicalArmsLpc-37, Placebo
3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Probiotics for the treatment of depression and its comorbidities: A systemic review.Frontiers in cellular and infection microbiology · 2023
    Pooled it
  2. Pooled it
  3. Trial
  4. Review
  5. Article
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  7. Article
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  10. Dissociative Symptoms and Interoceptive Integration.Current topics in behavioral neurosciences · 2025
    Review
  11. Article
  12. Review
  13. Review
  14. Review
  15. Review
  16. Review
  17. Article
  18. The critical role of gut microbiota in obesity.Frontiers in endocrinology · 2022
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Timothy G DinanDepartment of Psychiatry and Neurobehavioural Science, University College Cork, Cork, T12 YN60, Ireland. t.dinan@ucc.ie.
John F CryanAPC Microbiome Institute, University College Cork, Cork, T12 YN60, Ireland. j.cryan@ucc.ie.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is a growing realization that the gut-brain axis plays a key role in maintaining brain health and the stress response. Recently, the gut microbiota has emerged as a master regulator of this axis. Thus, opportunities to exploit the microbiome to treat stress-related psychiatric disorders are materializing. Clinical validation of such strategies is now warranted.

Indexed as

AffectMicrobiotaBrainDepressionGastrointestinal MicrobiomeGastrointestinal TractHomeostasisHumansMental HealthStress, PhysiologicalStress, Psychological

Identifiers

PMID27048547
PMCPMC4822287

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.