ArticleEuropean radiology2017
Detection of Functional Homotopy in Traumatic Axonal Injury.
Article in European radiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
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- Aberrant dynamic functional network connectivity in patients with diffuse axonal injury.Scientific reports · 2024Article
- Disrupted topological organization of functional brain networks in traumatic axonal injury.Brain imaging and behavior · 2024Article
- Enhanced interhemispheric resting-state functional connectivity of the visual network is an early treatment response of paroxetine in patients with panic disorder.European archives of psychiatry and clinical neuroscience · 2024Article
- The Relationship Between Cortical Morphological and Functional Topological Properties and Clinical Manifestations in Patients with Posttraumatic Diffuse Axonal Injury: An Individual Brain Network Study.Brain topography · 2023Article
- Reduced homotopic interhemispheric connectivity in psychiatric disorders: evidence for both transdiagnostic and disorder specific features.Psychoradiology · 2022Review
- Decreased Interhemispheric Functional Connectivity and Its Associations with Clinical Correlates following Traumatic Brain Injury.BioMed research international · 2022Observational
- Disrupted hypothalamic functional connectivity related to cognitive impairment after diffuse axonal injury.Medicine · 2021Observational
- Higher inter-hemispheric homotopic connectivity in lifelong premature ejaculation patients: a pilot resting-state fMRI study.Quantitative imaging in medicine and surgery · 2021Article
- Voxel-Wise Analysis of Structural and Functional MRI for Lateralization of Handedness in College Students.Frontiers in human neuroscience · 2021Article
- Frontal White Matter Hyperintensities Effect on Default Mode Network Connectivity in Acute Mild Traumatic Brain Injury.Frontiers in aging neuroscience · 2021Article
- Altered interhemispheric synchrony in Parkinson's disease patients with levodopa-induced dyskinesias.NPJ Parkinson's disease · 2020Article
- Unilateral thalamic glioma disrupts large-scale functional architecture of human brain during resting state.Neuropsychiatric disease and treatment · 2019Article
- Severe asymptomatic carotid stenosis is associated with robust reductions in homotopic functional connectivity.NeuroImage. Clinical · 2019Article
- Thalamic atrophy and dysfunction in patients with mild-to-moderate traumatic diffuse axonal injury: a short-term and mid-term MRI study.Neuroreport · 2018Article
- Characterizing Signals Within Lesions and Mapping Brain Network Connectivity After Traumatic Axonal Injury: A 7 Tesla Resting-State FMRI Study.Brain connectivity · 2018Article
- Disrupted interhemispheric functional connectivity in chronic insomnia disorder: a resting-state fMRI study.Neuropsychiatric disease and treatment · 2018Article
- Reduction of Interhemispheric Functional Brain Connectivity in Early Blindness: A Resting-State fMRI Study.BioMed research international · 2017Article
- Altered homotopic connectivity in postherpetic neuralgia: a resting state fMRI study.Journal of pain research · 2016Article
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aimed to explore the interhemispheric intrinsic connectivity in traumatic axonal injury (TAI) patients.
methodsTwenty-one patients with TAI (14 males, seven females; mean age, 38.71 ± 15.25 years) and 22 well-matched healthy controls (16 males, six females; mean age, 38.50 ± 13.82 years) were recruited, and from them we obtained resting-state fMRI data. Interhemispheric coordination was examined using voxel-mirrored homotopic connectivity (VMHC) and seed-based functional connectivity analysis was performed.
resultsWe observed significantly decreased VMHC in a number of regions in TAI patients, including the prefrontal, temporal, occipital, parietal, and posterior cingulate cortices, thalami and cerebellar posterior lobes. Subsequent seed-based functional connectivity analysis revealed widely disrupted functional connectivity between the regions of local homotopic connectivity deficits and other areas of the brain, particularly the areas subserving the default, salience, integrative, and executive systems. The lower VMHC of the inferior frontal gyrus and basal ganglia, thalamus, and caudate were significant correlated with the Beck Depression Inventory score, Clinical Dementia Rating score, and Mini-Mental State Examination score, respectively.
conclusionTAI is associated with regionally decreased interhemispheric interactions and extensively disrupted seed-based functional connectivity, generating further evidence of diffuse disconnection being associated with clinical symptoms in TAI patients. KEY POINTS: • Traumatic axonal injury is associated with decreased interhemispheric connectivity • Traumatic axonal injury couples with widely disrupted functional connectivity • These alterations support the default, salience, integrative, and executive functions.
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