Evidence map›Paper›PMID 27048444›Full record

SynthesisMolecular neurobiology2017

PICALM rs3851179 Variant Confers Susceptibility to Alzheimer's Disease in Chinese Population.

Guiyou Liu, Yining Xu, Yongshuai Jiang, Liangcai Zhang, Rennan Feng, Qinghua Jiang

Abstract readMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Molecular neurobiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 7 syntheses or guidelines pooled it.

  1. Association between theFrontiers in physiology · 2023
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  2. Different Associations Between theFrontiers in genetics · 2020
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  13. Association ofFrontiers in genetics · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Guiyou LiuSchool of Life Science and Technology, Harbin Institute of Technology, Room 415, Building 2E, Science Park, Yikuang Street, Nangang District, Harbin, 150080, China.
Yining XuSchool of Computer Science and Technology, Harbin Institute of Technology, Harbin, China.
Yongshuai JiangCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
Liangcai ZhangDepartment of Statistics, Rice University, Houston, TX, USA.
Rennan FengDepartment of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin, China.
Qinghua JiangSchool of Life Science and Technology, Harbin Institute of Technology, Room 415, Building 2E, Science Park, Yikuang Street, Nangang District, Harbin, 150080, China. qhjiang@hit.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The association between PICALM rs3851179 variant and Alzheimer's disease (AD) has been well established by previous genome-wide association studies (GWAS) and candidate gene studies in European population. Recent studies investigated the association between PICALM rs3851179 and AD susceptibility in Chinese population. However, these studies reported consistent and inconsistent results. Here, we selected 9435 samples including 3704 AD cases and 5731 controls from previous studies and evaluated this association using a meta-analysis method for additive model. We did not observe significant genetic heterogeneity in Chinese population. Our results indicate significant association between PICALM rs3851179 and AD in Chinese population. The sensitivity analysis indicates that the association between rs3851179 and AD did not vary substantially. The regression analysis suggests no significant publication bias. In summary, this updated meta-analysis highlights the involvement of PICALM rs3851179 variant in Alzheimer's disease susceptibility in Chinese population.

Indexed as

Genetic Predisposition to DiseaseAlzheimer DiseaseAsian PeopleHumansMonomeric Clathrin Assembly ProteinsPolymorphism, Single NucleotidePublication BiasMonomeric Clathrin Assembly ProteinsPICALM protein, humanAlzheimer’s diseaseChinese populationGenome-wide association studyPICALMrs3851179

Identifiers

PMID27048444

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.