SynthesisBMC psychiatry2016
Is adherence therapy an effective adjunct treatment for patients with schizophrenia spectrum disorders? A systematic review and meta-analysis.
Synthesis in BMC psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 50 citations in OpenAlex.
- Simple Mobile technology health management tool for people with severe mental illness: a randomised controlled feasibility trial.BMC psychiatry · 2021Trial
- Ethical acceptability of offering financial incentives for taking antipsychotic depot medication: patients' and clinicians' perspectives after a 12-month randomized controlled trial.BMC psychiatry · 2017Trial
- Effectiveness of M-Health Interventions to Improve Medication Adherence in People with Schizophrenia Spectrum Disorder: A Systematic Review.Nursing reports (Pavia, Italy) · 2026Review
- Analysis of medication adherence and its influencing factors in outpatients with mental disorders: a mixed study in eastern of China.Scientific reports · 2026Article
- Intrinsic capacity decline and intervention needs among older adults in a rural northern Chinese village: a qualitative study.BMC geriatrics · 2026Article
- Effectiveness of Cognitive and Behavioral Interventions in the Treatment of Schizophrenia: An Umbrella Review of Meta-Analyses.Journal of clinical medicine · 2025Review
- Technology-Based Strategy to Improve Medication Compliance Among Patients With Schizophrenia Spectrum Disorders.Cureus · 2024Article
- Adherence therapy for adults with type 2 diabetes: a feasibility study of a randomized controlled trial.Pilot and feasibility studies · 2023Article
- A Systematic Review and Meta-Analysis of the Effectiveness of Adherence Therapy and Its Treatment Duration in Patients with Schizophrenia Spectrum Disorders.Patient preference and adherence · 2023Review
- The Safety and Efficacy of Psychosocial Adherence Interventions in Young People with Early Psychosis: A Systematic Review.Healthcare (Basel, Switzerland) · 2022Review
- Non-pharmacological interventions for schizophrenia-analysis of treatment guidelines and implementation in 12 Southeast European countries.Schizophrenia (Heidelberg, Germany) · 2022Article
- Healthcare Provider Engagement with a Novel Dashboard for Tracking Medication Ingestion: Impact on Treatment Decisions and Clinical Assessments for Adults with Schizophrenia.Neuropsychiatric disease and treatment · 2022Article
- Interventions to Improve Medication Adherence in People with Schizophrenia: A Systematic Review.Patient preference and adherence · 2022Review
- A study protocol for a feasibility trial of telephone-delivered Adherence Therapy for adults with type 2 diabetes.Nursing open · 2021Article
- Identification of Risk Factors to Predict the Occurrences of Relapses in Individuals with Schizophrenia Spectrum Disorder in Iran.International journal of environmental research and public health · 2021Article
- Gender Differences of Schizophrenia Patients With and Without Depressive Symptoms in Clinical Characteristics.Frontiers in psychiatry · 2021Article
- [Motivational interviewing : A possibility for doctor-patient communication in schizophrenia?]Der Nervenarzt · 2019Review
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Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 8 institutions in 7 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPoor adherence to medication in schizophrenia spectrum disorders leads to inadequate symptom control. Adherence therapy (AT) is an intervention that seeks to reduce patients' psychiatric symptoms by enhancing treatment adherence. We aimed to systematically review the trial evidence of the effectiveness of AT on improving clinical outcomes in these patients.
methodSystematic review and meta-analysis of published RCTs. We included studies testing AT as an adjunct intervention against treatment as usual or a comparator intervention in the general adult psychiatric population. The primary outcome of interest was improvement in psychiatric symptoms.
resultsWe included six studies testing AT in schizophrenia spectrum disorders published since 2006. A meta-analysis showed AT significantly reduced psychiatric symptoms compared to usual treatment over a follow-up period of less than 1 year. We found no significant effects of AT on patients' adherence and adherence attitudes.
conclusionsAT is an effective adjunctive treatment for people with schizophrenia spectrum disorders. PROSPERO: CRD42015016779.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.