Trial reportHarm reduction journal2016
Correlates of cocaine use during methadone treatment: implications for screening and clinical management (ANRS Methaville study).
Trial report in Harm reduction journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Initialization of Methadone in Primary Care; a Randomized Intervention Research for Preventing HCV Transmission Practices. ANRS Methaville
Screen, Treat and Retain Meth-using People With Opioid Use Disorders at Methadone Clinics
Who cites it
15 citing papers in PubMed, 33 citations in OpenAlex.
- A randomized clinical trial of disulfiram at higher doses for the treatment of cocaine use disorder among methadone-stabilized patients.Journal of psychiatric research · 2025Trial
- Article
- The influence of poly-drug use patterns on the association between opioid agonist treatment engagement and injecting initiation assistance.Substance abuse treatment, prevention, and policy · 2022Article
- Article
- Modafinil Does Not Reduce Cocaine Use in Methadone-Maintained Individuals.Drug and alcohol dependence reports · 2022Article
- "The idea is to help people achieve greater success and liberty": A qualitative study of expanded methadone take-home access in opioid use disorder treatment.Substance abuse · 2022Article
- Use of sustained release dextroamphetamine for the treatment of stimulant use disorder in the setting of injectable opioid agonist treatment in Canada: a case report.Harm reduction journal · 2021Article
- The Role of Risk or Contributory Death Factors in Methadone-Related Fatalities: A Review and Pooled Analysis.Metabolites · 2021Article
- Gender Differences in Patterns and Correlates of Continued Substance Use among Patients in Methadone Maintenance Treatment.Substance use & misuse · 2021Article
- Tackling the overdose crisis: The role of safe supply.The International journal on drug policy · 2020Article
- Understanding concurrent stimulant use among people on methadone: A qualitative study.Drug and alcohol review · 2020Article
- Prediction of stress and drug craving ninety minutes in the future with passively collected GPS data.NPJ digital medicine · 2020Article
- Attention Deficit Hyperactivity Disorder, Aggression, and Illicit Stimulant Use: Is This Self-Medication?The Journal of nervous and mental disease · 2017Article
- The impact of comorbid psychiatric disorders on methadone maintenance treatment in opioid use disorder: a prospective cohort study.Neuropsychiatric disease and treatment · 2017Article
- Evaluating the Impact of Prescribed Versus Nonprescribed Benzodiazepine Use in Methadone Maintenance Therapy: Results From a Population-based Retrospective Cohort Study.Journal of addiction medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCocaine use is frequent in patients receiving methadone maintenance treatment (MMT) and can jeopardize their treatment response. Identifying clinical predictors of cocaine use during methadone treatment can potentially improve clinical management. We used longitudinal data from the ANRS Methaville trial both to describe self-reported occasional and regular cocaine use during MMT and to identify clinical predictors.
methodsWe selected 183 patients who had data on cocaine (or crack) use at months 0 (M0), M6, and/or M12, accounting for 483 visits. The outcome was "cocaine use" in three categories: "no," "occasional," and "regular" use. To identify factors associated with the outcome over time, we performed a mixed multinomial logistic regression.
resultsTime on methadone was significantly associated with a decrease in occasional but not in regular cocaine use from 14.7% at M0 to 7.1% at M12, and from 10.7% at baseline to 6.5% at M12, respectively. After multiple adjustments, opiate injection, individuals screening positive for attention deficit hyperactivity disorder (ADHD) symptoms, and those presenting depressive symptoms were more likely to regularly use cocaine.
conclusionsAlthough time on MMT had a positive impact on occasional cocaine use, it had no impact on regular cocaine use. Moreover, regular cocaine users were more likely to report opiate injection and to present ADHD and depressive symptoms. Early screening of these disorders and prompt tailored pharmacological and behavioral interventions can potentially reduce cocaine use and improve response to MMT.
trial registrationThe trial is registered with the French Agency of Pharmaceutical Products (AFSSAPS) under the number 2008-A0277-48, the European Union Drug Regulating Authorities Clinical Trials, number Eudract 2008-001338-28, the ClinicalTrials.gov Identifier: NCT00657397 , and the International Standard Randomised Controlled Trial Number Register ISRCTN31125511.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.