Evidence map›Paper›PMID 27048150›Full record

ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2016

Resective surgery for focal cortical dysplasia in children: a comparative analysis of the utility of intraoperative magnetic resonance imaging (iMRI).

Matthew F Sacino, Cheng-Ying Ho, Matthew T Whitehead, Tesfaye Zelleke, Suresh N Magge, John Myseros, Robert F Keating, William D Gaillard, Chima O Oluigbo

Abstract read
PubMed Publisher
In one paragraph

Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. The impact of intraoperative magnetic resonance in routine pediatric neurosurgical practice-a 6-year appraisal.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2018
    Article
  5. An initial cost-effectiveness analysis of intraoperative magnetic resonance imaging (iMRI) in pediatric epilepsy surgery.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2018
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Matthew F SacinoDepartment of Neurosurgery, Children's National Medical Center, 111 Michigan Avenue NW, Washington, DC, 20010, USA.
Cheng-Ying HoDepartment of Neuropathology, Children's National Medical Center, Washington, DC, 20010, USA.
Matthew T WhiteheadDepartment of Neuroradiology, Children's National Medical Center, Washington, DC, 20010, USA.
Tesfaye ZellekeDepartment of Neurology, Children's National Medical Center, Washington, DC, 20010, USA.
Suresh N MaggeDepartment of Neurosurgery, Children's National Medical Center, 111 Michigan Avenue NW, Washington, DC, 20010, USA.
John MyserosDepartment of Neurosurgery, Children's National Medical Center, 111 Michigan Avenue NW, Washington, DC, 20010, USA.
Robert F KeatingDepartment of Neurosurgery, Children's National Medical Center, 111 Michigan Avenue NW, Washington, DC, 20010, USA.
William D GaillardDepartment of Neurology, Children's National Medical Center, Washington, DC, 20010, USA.
Chima O OluigboDepartment of Neurosurgery, Children's National Medical Center, 111 Michigan Avenue NW, Washington, DC, 20010, USA. coluigbo@cnmc.org.
Children's National · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeSeizure freedom following resection of focal cortical dysplasia (FCD) correlates with complete resection of the dysplastic cortical tissue. However, difficulty with intraoperative identification of the lesion may limit the ability to achieve the surgical objective of complete extirpation of these lesions. Intraoperative magnetic resonance imaging (iMRI) may aid in FCD resections. The objective of this study is to compare rates of postoperative seizure freedom, completeness of resection, and need for reoperation in patients undergoing iMRI-assisted FCD resection versus conventional surgical techniques.

methodsWe retrospectively reviewed the medical records of pediatric subjects who underwent surgical resection of FCD at Children's National Medical Center between March 2005 and April 2015.

resultsAt the time of the last postoperative follow-up, 11 of the 12 patients (92 %) in the iMRI resection group were seizure free (Engel Class I), compared to 14 of the 42 patients (33 %) in the control resection group (p = 0.0005). All 12 of the iMRI patients (100 %) achieved complete resection, compared to 24 of 42 patients (57 %) in the control group (p = 0.01). One (8 %) patient from the iMRI-assisted resection group has required reoperation, compared to 17 (40 %) patients in the control resection group.

conclusionOur results suggest that the utilization of iMRI during surgery for resection of FCD results in improved postoperative seizure freedom, completeness of lesion resection, and reduction in the need for reoperation.

Indexed as

BrainChildElectrocardiographyFemaleFollow-Up StudiesHumansKaplan-Meier EstimateMagnetic Resonance ImagingMaleMalformations of Cortical DevelopmentMonitoring, IntraoperativeNeurosurgical ProceduresRetrospective StudiesTreatment OutcomeEpilepsy surgeryFocal Cortical DysplasiaIntraoperative MRIPediatricUtility

Identifiers

PMID27048150
OpenAlexW2328679029

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.