Evidence map›Paper›PMID 27047968›Full record

ArticleJournal of arthropod-borne diseases2016

Assessment of Recombination in the S-segment Genome of Crimean-Congo Hemorrhagic Fever Virus in Iran.

Sadegh Chinikar, Nariman Shah-Hosseini, Saeid Bouzari, Mohammad Ali Shokrgozar, Ehsan Mostafavi, Tahmineh Jalali, Sahar Khakifirouz, Martin H Groschup, Matthias Niedrig

Abstract read
In one paragraph

Article in Journal of arthropod-borne diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
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  10. Current status of Crimean-Congo haemorrhagic fever in the World Health Organization Eastern Mediterranean Region: issues, challenges, and future directions.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2017
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sadegh ChinikarArboviruses and Viral Hemorrhagic Fevers Laboratory (National Reference Lab), Pasteur Institute of Iran, Tehran, Iran.
Nariman Shah-HosseiniArboviruses and Viral Hemorrhagic Fevers Laboratory (National Reference Lab), Pasteur Institute of Iran, Tehran, Iran.
Saeid BouzariDepartment of Molecular Biology, Pasteur Institute of Iran, Tehran, Iran.
Mohammad Ali ShokrgozarNational Cell Bank of Iran, Pasteur Institute of Iran, Tehran, Iran.
Ehsan MostafaviDepartment of Epidemiology, Pasteur Institute of Iran, Tehran, Iran.
Tahmineh JalaliArboviruses and Viral Hemorrhagic Fevers Laboratory (National Reference Lab), Pasteur Institute of Iran, Tehran, Iran.
Sahar KhakifirouzArboviruses and Viral Hemorrhagic Fevers Laboratory (National Reference Lab), Pasteur Institute of Iran, Tehran, Iran.
Martin H GroschupFriedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald-Insel Riems, Germany.
Matthias NiedrigRobert Koch Institute, Berlin, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCrimean-Congo Hemorrhagic Fever Virus (CCHFV) belongs to genus Nairovirus and family Bunyaviridae. The main aim of this study was to investigate the extent of recombination in S-segment genome of CCHFV in Iran.

methodsSamples were isolated from Iranian patients and those available in GenBank, and analyzed by phylogenetic and bootscan methods.

resultsThrough comparison of the phylogenetic trees based on full length sequences and partial fragments in the S-segment genome of CCHFV, genetic switch was evident, due to recombination event. Moreover, evidence of multiple recombination events was detected in query isolates when bootscan analysis was used by SimPlot software.

conclusionSwitch of different genomic regions between different strains by recombination could contribute to CCHFV diversification and evolution. The occurrence of recombination in CCHFV has a critical impact on epidemiological investigations and vaccine design.

Indexed as

Crimean Congo Hemorrhagic FeverDiversityIranPhylogeneticRecombination

Identifiers

PMID27047968
PMCPMC4813403

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.