ReviewBioMed research international2016
In Vivo Laser Scanning Confocal Microscopy of Human Meibomian Glands in Aging and Ocular Surface Diseases.
Review in BioMed research international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 32 citations in OpenAlex.
- Correlating corneal and meibomian gland morphology with diabetes duration in T2DMInternational journal of ophthalmology · 2026Article
- Accelerated Biological Aging and Genetic Pleiotropy in Age-Related Eye Diseases: A Population-Based Cohort and Integrative Genetic Analysis.Investigative ophthalmology & visual science · 2025Article
- Cytokines in age-related eye diseases: pathogenesis and potential targets for innovative therapies.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- In vivo Confocal Microscopy for Corneal and Ocular Surface Pathologies: A Comprehensive Review.Clinical ophthalmology (Auckland, N.Z.) · 2025Review
- Meibomian gland alterations in allergic conjunctivitis: insights from a novel quantitative analysis algorithm.Frontiers in cell and developmental biology · 2024Article
- Impacts of gender and age on meibomian gland in aged people using artificial intelligence.Frontiers in cell and developmental biology · 2023Article
- Vision through Healthy Aging Eyes.Vision (Basel, Switzerland) · 2021Review
- Confocal Microscopy and Anterior Segment Optical Coherence Tomography Imaging of the Ocular Surface and Bleb Morphology in Medically and Surgically Treated Glaucoma Patients: A Review.Pharmaceuticals (Basel, Switzerland) · 2021Review
- Age differences in ocular demodicosis: Demodex profiles and clinical manifestations.Annals of translational medicine · 2021Article
- Artificial Intelligence to Detect Meibomian Gland Dysfunction FromFrontiers in medicine · 2021Article
- The protective effect of 3% diquafosol on meibomian gland morphology in glaucoma patients treated with prostaglandin analogs: a 12-month follow-up study.BMC ophthalmology · 2020Article
- A Review of Imaging Biomarkers of the Ocular Surface.Eye & contact lens · 2020Review
- Meibomian Glands or Not? Identification of In Vivo and Ex Vivo Confocal Microscopy Features and Histological Correlates in the Eyelid Margin.Journal of ophthalmology · 2020Article
- Effects of Preservative on the Meibomian Gland in Glaucoma Patients Treated with Prostaglandin Analogues.Chonnam medical journal · 2019Article
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- Morphological and cytological changes of meibomian glands in patients with type 2 diabetes mellitus.International journal of ophthalmology · 2019Article
- Clinically Relevant Immune-Cellular Metrics of Inflammation in Meibomian Gland Dysfunction.Investigative ophthalmology & visual science · 2018Article
- Wide-Field In Vivo Confocal Microscopy of Meibomian Gland Acini and Rete Ridges in the Eyelid Margin.Investigative ophthalmology & visual science · 2018Article
- Ocular surface inflammation impairs structure and function of meibomian gland.Experimental eye research · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Meibomian glands (MGs) play a crucial role in the ocular surface homeostasis by providing lipids to the superficial tear film. Their dysfunction destabilizes the tear film leading to a progressive loss of the ocular surface equilibrium and increasing the risk for dry eye. In fact, nowadays, the meibomian gland dysfunction is one of the leading causes of dry eye. Over the past decades, MGs have been mainly studied by using meibography, which, however, cannot image the glandular structure at a cellular level. The diffusion of the in vivo laser scanning confocal microscopy (LSCM) provided a new approach for the structural assessment of MGs permitting a major step in the noninvasive evaluation of these structures. LSCM is capable of showing MGs modifications during aging and in the most diffuse ocular surface diseases such as dry eye, allergy, and autoimmune conditions and in the drug-induced ocular surface disease. On the other hand, LSCM may help clinicians in monitoring the tissue response to therapy. In this review, we summarized the current knowledge about the role of in vivo LSCM in the assessment of MGs during aging and in the most diffuse ocular surface diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.