Evidence map›Paper›PMID 27047946›Full record

ArticleAnnals of translational medicine2016

Chest CT abnormalities and quality of life: relationship in adult cystic fibrosis.

Aoife Kilcoyne, Lisa P Lavelle, Colin J McCarthy, Sinead H McEvoy, Hannah Fleming, Annika Gallagher, Martine Loeve, Harm Tiddens, Edward McKone, Charles C Gallagher and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of translational medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Aoife Kilcoyne1 Department of Radiology, 2 National Referral Centre for Adult Cystic Fibrosis, St. Vincent's University Hospital, Elm Park, Dublin, Ireland ; 3 Department of Pediatric Pulmonology, Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands ; 4 Department of Radiology, Erasmus MC, Rotterdam, The Netherlands.
Lisa P Lavelle1 Department of Radiology, 2 National Referral Centre for Adult Cystic Fibrosis, St. Vincent's University Hospital, Elm Park, Dublin, Ireland ; 3 Department of Pediatric Pulmonology, Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands ; 4 Department of Radiology, Erasmus MC, Rotterdam, The Netherlands.
Colin J McCarthy1 Department of Radiology, 2 National Referral Centre for Adult Cystic Fibrosis, St. Vincent's University Hospital, Elm Park, Dublin, Ireland ; 3 Department of Pediatric Pulmonology, Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands ; 4 Department of Radiology, Erasmus MC, Rotterdam, The Netherlands.
Sinead H McEvoy1 Department of Radiology, 2 National Referral Centre for Adult Cystic Fibrosis, St. Vincent's University Hospital, Elm Park, Dublin, Ireland ; 3 Department of Pediatric Pulmonology, Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands ; 4 Department of Radiology, Erasmus MC, Rotterdam, The Netherlands.
Hannah Fleming1 Department of Radiology, 2 National Referral Centre for Adult Cystic Fibrosis, St. Vincent's University Hospital, Elm Park, Dublin, Ireland ; 3 Department of Pediatric Pulmonology, Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands ; 4 Department of Radiology, Erasmus MC, Rotterdam, The Netherlands.
Annika Gallagher1 Department of Radiology, 2 National Referral Centre for Adult Cystic Fibrosis, St. Vincent's University Hospital, Elm Park, Dublin, Ireland ; 3 Department of Pediatric Pulmonology, Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands ; 4 Department of Radiology, Erasmus MC, Rotterdam, The Netherlands.
Martine Loeve1 Department of Radiology, 2 National Referral Centre for Adult Cystic Fibrosis, St. Vincent's University Hospital, Elm Park, Dublin, Ireland ; 3 Department of Pediatric Pulmonology, Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands ; 4 Department of Radiology, Erasmus MC, Rotterdam, The Netherlands.
Harm Tiddens1 Department of Radiology, 2 National Referral Centre for Adult Cystic Fibrosis, St. Vincent's University Hospital, Elm Park, Dublin, Ireland ; 3 Department of Pediatric Pulmonology, Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands ; 4 Department of Radiology, Erasmus MC, Rotterdam, The Netherlands.
Edward McKone1 Department of Radiology, 2 National Referral Centre for Adult Cystic Fibrosis, St. Vincent's University Hospital, Elm Park, Dublin, Ireland ; 3 Department of Pediatric Pulmonology, Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands ; 4 Department of Radiology, Erasmus MC, Rotterdam, The Netherlands.
Charles C Gallagher1 Department of Radiology, 2 National Referral Centre for Adult Cystic Fibrosis, St. Vincent's University Hospital, Elm Park, Dublin, Ireland ; 3 Department of Pediatric Pulmonology, Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands ; 4 Department of Radiology, Erasmus MC, Rotterdam, The Netherlands.
Jonathan D Dodd1 Department of Radiology, 2 National Referral Centre for Adult Cystic Fibrosis, St. Vincent's University Hospital, Elm Park, Dublin, Ireland ; 3 Department of Pediatric Pulmonology, Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands ; 4 Department of Radiology, Erasmus MC, Rotterdam, The Netherlands.
Erasmus MC · NLErasmus University Rotterdam · NLErasmus MC - Sophia Children’s Hospital · NLSt. Vincent's University Hospital · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo evaluate the relationship between lung parenchymal abnormalities on chest CT and health-related quality of life in adult cystic fibrosis (CF).

methodsThe chest CT scans of 101 consecutive CF adults (mean age 27.8±7.9, 64 males) were prospectively scored by two blinded radiologists in consensus using a modified Bhalla score. Health-related quality of life was assessed using the revised Quittner Cystic Fibrosis Questionnaire (CFQ-R). Multiple regressions were performed with each of the CFQ-R domains and all clinical and imaging findings to assess independent correlations.

resultsThere were 18 inpatients and 83 outpatients. For the cohort of inpatients, CT abnormalities were significantly (P<0.005 for all) associated with Respiratory Symptoms (Air Trapping), and also with Social Functioning (Consolidation) and Role Functioning (Consolidation). For outpatients, CT abnormalities were significantly (P<0.005 for all) associated with Respiratory Symptoms (Consolidation) and also with Physical Functioning (Consolidation), Vitality (Consolidation, Severity of Bronchiectasis), Eating Problems (airway wall thickening), Treatment Burden (Total CT Score), Body Image (Severity of Bronchiectasis) and Role Functioning (Tree-in-bud nodules). Consolidation was the commonest independent CT predictor for both inpatients (predictor for 2 domains) and outpatients (predictor in 3 domains). Several chest CT abnormalities excluded traditional measures such as FEV1 and BMI from the majority of CFQ-R domains.

conclusionsChest CT abnormalities are significantly associated with quality of life measures in adult CF, independent of clinical or spirometric measurements.

Indexed as

Computed tomography (CT)cysticfibrosispulmonaryquality of life

Identifiers

PMID27047946
PMCPMC4791339
OpenAlexW2340595711

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.