ArticleFrontiers in public health2016
Risk Associated with the Release of Wolbachia-Infected Aedes aegypti Mosquitoes into the Environment in an Effort to Control Dengue.
Article in Frontiers in public health, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed.
- Changes in the frequency of facultative endosymbionts in insect populations: overview and applications.Entomologia generalis · 2025Article
- Potential effect ofFrontiers in microbiology · 2025Article
- Review
- Mosquito Microbiomes of Rwanda: Characterizing Mosquito Host and Microbial Communities in the Land of a Thousand Hills.Microbial ecology · 2024Article
- Mitigating dengue transmission in Africa: the need forFrontiers in public health · 2024Article
- Holobiont perspectives on tripartite interactions among microbiota, mosquitoes, and pathogens.The ISME journal · 2023Review
- A rapidly spreading deleterious aphid endosymbiont that uses horizontal as well as vertical transmission.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Importance ofBiosafety and health · 2023Review
- Risk Assessment on the Release ofInsects · 2022Article
- Transient Introgression ofPathogens (Basel, Switzerland) · 2022Article
- Assessment of fitness and vector competence of a New Caledonia wMel Aedes aegypti strain before field-release.PLoS neglected tropical diseases · 2021Article
- UsingJournal of virology · 2021Review
- Modelling the Wolbachia incompatible insect technique: strategies for effective mosquito population elimination.BMC biology · 2020Article
- Adequacy and sufficiency evaluation of existing EFSA guidelines for the molecular characterisation, environmental risk assessment and post-market environmental monitoring of genetically modified insects containing engineered gene drives.EFSA journal. European Food Safety Authority · 2020Article
- Chimeric symbionts expressing a Wolbachia protein stimulate mosquito immunity and inhibit filarial parasite development.Communications biology · 2020Article
- Evolutionary Ecology ofAnnual review of genetics · 2019Review
- Combined sterile insect technique and incompatible insect technique: The first proof-of-concept to suppress Aedes aegypti vector populations in semi-rural settings in Thailand.PLoS neglected tropical diseases · 2019Article
- Using problem formulation for fit-for-purpose pre-market environmental risk assessments of regulated stressors.EFSA journal. European Food Safety Authority · 2019Article
- Cytoplasmic incompatibility management to support Incompatible Insect Technique against Aedes albopictus.Parasites & vectors · 2018Article
- Controlling vector-borne diseases by releasing modified mosquitoes.Nature reviews. Microbiology · 2018Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn an effort to eliminate dengue, a successful technology was developed with the stable introduction of the obligate intracellular bacteria Wolbachia pipientis into the mosquito Aedes aegypti to reduce its ability to transmit dengue fever due to life shortening and inhibition of viral replication effects. An analysis of risk was required before considering release of the modified mosquito into the environment.
methodsExpert knowledge and a risk assessment framework were used to identify risk associated with the release of the modified mosquito. Individual and group expert elicitation was performed to identify potential hazards. A Bayesian network (BN) was developed to capture the relationship between hazards and the likelihood of events occurring. Risk was calculated from the expert likelihood estimates populating the BN and the consequence estimates elicited from experts.
resultsThe risk model for "Don't Achieve Release" provided an estimated 46% likelihood that the release would not occur by a nominated time but generated an overall risk rating of very low. The ability to obtain compliance had the greatest influence on the likelihood of release occurring. The risk model for "Cause More Harm" provided a 12.5% likelihood that more harm would result from the release, but the overall risk was considered negligible. The efficacy of mosquito management had the most influence, with the perception that the threat of dengue fever had been eliminated, resulting in less household mosquito control, and was scored as the highest ranked individual hazard (albeit low risk).
conclusionsThe risk analysis was designed to incorporate the interacting complexity of hazards that may affect the release of the technology into the environment. The risk analysis was a small, but important, implementation phase in the success of this innovative research introducing a new technology to combat dengue transmission in the environment.
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