Evidence map›Paper›PMID 27047770›Full record

ArticleJournal of clinical and translational hepatology2016

Curing Hepatitis C in Liver Transplant Recipients Is Associated with Changes in Immunosuppressant Use.

Sammy Saab, Justin Rheem, Melissa Jimenez, Sherona Bau, Gina Choi, Francisco Durazo, Mohammed El Kabany, Steven Han, Alexander Farid, Naadir Jamal and 3 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical and translational hepatology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Article
  3. Impact of direct-acting antivirals for hepatitis C virus therapy on tacrolimus dosing in liver transplant recipients.Transplant infectious disease : an official journal of the Transplantation Society · 2019
    Article
  4. Elimination of Hepatitis C in Liver Transplant Recipients.Journal of clinical and translational hepatology · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Sammy SaabDepartments of Medicine at the University of California at Los Angeles, Los Angeles, California, USA; Department of Surgery at the University of California at Los Angeles, Los Angeles, California, USA.
Justin RheemDepartment of Medicine at Harbor-University of California at Los Angeles Medical Center, Torrance, California, USA.
Melissa JimenezDepartments of Medicine at the University of California at Los Angeles, Los Angeles, California, USA.
Sherona BauDepartment of Surgery at the University of California at Los Angeles, Los Angeles, California, USA.
Gina ChoiDepartments of Medicine at the University of California at Los Angeles, Los Angeles, California, USA; Department of Surgery at the University of California at Los Angeles, Los Angeles, California, USA.
Francisco DurazoDepartments of Medicine at the University of California at Los Angeles, Los Angeles, California, USA; Department of Surgery at the University of California at Los Angeles, Los Angeles, California, USA.
Mohammed El KabanyDepartments of Medicine at the University of California at Los Angeles, Los Angeles, California, USA; Department of Surgery at the University of California at Los Angeles, Los Angeles, California, USA.
Steven HanDepartments of Medicine at the University of California at Los Angeles, Los Angeles, California, USA; Department of Surgery at the University of California at Los Angeles, Los Angeles, California, USA.
Alexander FaridDepartments of Medicine at the University of California at Los Angeles, Los Angeles, California, USA.
Naadir JamalDepartments of Medicine at the University of California at Los Angeles, Los Angeles, California, USA.
Jonathan GrottsDepartments of Medicine at the University of California at Los Angeles, Los Angeles, California, USA.
David ElashoffDepartments of Medicine at the University of California at Los Angeles, Los Angeles, California, USA; Department of Biostatistics at the University of California at Los Angeles, Los Angeles, California, USA.
Ronald W BusuttilDepartment of Surgery at the University of California at Los Angeles, Los Angeles, California, USA.
University of California, Los Angeles · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsAll-oral interferon-free antivirals are highly effective in treating recurrent hepatitis C (HCV) infection in liver transplant (LT) recipients. The aim of the study was to assess immunosuppression needs after achieving a sustained viral response (SVR).

methodsWe compared immunosuppression needs before and after achieving a SVR in adult LT recipients treated for recurrent HCV infection with all-oral direct acting agents.

resultsWe identified 52 liver LT treated recipients who achieved a SVR. The median (25th and 75th percentile interquartile range [IQR]) age was 62 years (57.75, 65). Most recipients received tacrolimus (TAC) for their immunosuppressant regimen. After achieving SVR, there was no statistically significant difference in daily dose of TAC unadjusted per weight (p > 0.05). However, there was a statistically significant decrease in daily dose of TAC adjusted per weight, serum levels of TAC, and the product of glomerular filtration rate and TAC. No statistically significant differences in cyclosporine unadjusted/adjusted per weight daily dose or serum levels were noted.

conclusionsImmunosuppression needs were increased for those patients treated with TAC but not cyclosporine. LT recipients prescribed TAC require close monitoring after treatment completion to avoid potential risk of acute rejection.

Indexed as

Direct acting agentsHepatitis CImmunosuppressantLiver transplantation

Identifiers

PMID27047770
PMCPMC4807141
OpenAlexW2321829671

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.