ArticleJournal of osteoporosis2016
Bone Strength and Arterial Stiffness Impact on Cardiovascular Mortality in a General Population.
Article in Journal of osteoporosis, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 21 citations in OpenAlex.
- Article
- Rapid trabecular bone growth in puberty associated with stiffer arteries in adulthood - longitudinal study on healthy young males.Archives of osteoporosis · 2023Article
- Sex-specific associations among total bone-specific physical activity score, aortic parameters, and body composition in healthy young adults.Journal of exercise science and fitness · 2022Article
- Brachial-ankle pulse wave velocity is associated with the risk of osteoporosis: a cross-sectional evidence from a Chinese community-based cohort.Journal of orthopaedic surgery and research · 2021Article
- Poor Bone Quality is Associated With Greater Arterial Stiffness: Insights From the UK Biobank.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2021Article
- Clinical characteristics of a group of deaths with COVID-19 pneumonia in Wuhan, China: a retrospective case series.BMC infectious diseases · 2020Article
- Association Between Arterial Stiffness, Frailty and Fall-Related Injuries in Older Adults.Vascular health and risk management · 2020Article
- Circulating miR-92a expression level in patients with essential hypertension: a potential marker of atherosclerosis.Journal of human hypertension · 2017Article
- The link between bone disease and cardiovascular complications in hemodialysis patients.Electronic physician · 2016Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteoporosis and increased arterial stiffness independently have been found to be associated with higher cardiovascular events rates in the general population (GP). We examined 558 patients from GP by dual-energy X-ray absorptiometry (DXA) and pulse wave velocity (PWV) measurements at baseline, with 36-month follow-up period. DXA assessed bone mineral density of femoral neck (BMD FN) and lumbar spine (BMD LS). Carotid-femoral PWV was assessed by pulsed-Doppler. The aim of our study is to find correlation between bone strength and arterial stiffness and their impact on cardiovascular mortality in GP. The mean ± SD of BMD FN, BMD LS, and PWV was 0.852 ± 0.1432 g/cm(2), 0.934 ± 0.1546 g/cm(2), and 9.209 ± 1.9815 m/s. In multiple regression analysis we found BMD FN (βst = -6.0094, p < 0.0001), hypertension (βst = 1.7340, p < 0.0091), and diabetes (βst = 0.4595, p < 0.0046). With Cox-regression analysis, after 17 cardiovascular events, the significant covariates retained by the backward model were BMD FN (b = -2.4129, p = 0.015) and PWV (b = 0.2606, p = 0.0318). The cut-off values were PWV = 9.4 m/s, BMD FN = 0.783 g/cm(2), and BMD LS = 0.992 g/cm(2). The results for BMD FN and PWV hazard ratio risk were 1.116 and 1.297, respectively. BMD FN as a measure of bone strength and PWV as a measure of arterial stiffness are strong independent predictors of cardiovascular mortality in GP.
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Registered trials
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