Evidence map›Paper›PMID 27047679›Full record

ReviewRegenerative biomaterials2016

The Quest toward limb regeneration: a regenerative engineering approach.

Cato T Laurencin, Lakshmi S Nair

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Regenerative biomaterials, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Development of porcine skeletal muscle extracellular matrix-derived hydrogels with improved properties and low immunogenicity.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  6. Bioengineering (Basel, Switzerland) · 2024
    Article
  7. Regenerative engineering of long bones using the small molecule forskolin.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Bioinspired Scaffold Designs for Regenerating Musculoskeletal Tissue Interfaces.Regenerative engineering and translational medicine · 2020
    Article
  14. Review
  15. Article
  16. Skeletal Muscle Regenerative Engineering.Regenerative engineering and translational medicine · 2019
    Article
  17. Article
  18. Mechanisms of urodele limb regeneration.Regeneration (Oxford, England) · 2017
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Cato T LaurencinDepartment of Orthopaedic Surgery, Institute for Regenerative Engineering, Raymond and Beverly Sackler Center for Biomedical, Biological, Physical and Engineering Sciences, University of Connecticut Health, Farmington, CT 06030, USA,; Department of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, USA,; Department of Materials Science and Engineering, University of Connecticut, Storrs, CT 06269, USA,; Department of Chemical and Biomolecular Engineering, University of Connecticut, Storrs, CT 06269, USA,; Department of Craniofacial Sciences, School of Dental Medicine, University of Connecticut Health, Farmington, CT 06030, USA.
Lakshmi S NairDepartment of Orthopaedic Surgery, Institute for Regenerative Engineering, Raymond and Beverly Sackler Center for Biomedical, Biological, Physical and Engineering Sciences, University of Connecticut Health, Farmington, CT 06030, USA,; Department of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, USA,; Department of Materials Science and Engineering, University of Connecticut, Storrs, CT 06269, USA.

Funding

Regenerative Engineering of Complex Musculoskeletal Tissues and JointsDP1AR068147 · NIAMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI LAURENCIN, CATO T. · 2014 to 2018
$4.1M
A Translational Approach Towards Ligament RegenerationR01AR063698 · NIAMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI LAURENCIN, CATO T. · 2013 to 2018
$1.9M
Enhanced Osteoinduction and Angioinduction via Polymer/CaO2 Bone Tissue EngineeriR21AR062771 · NIAMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI LAURENCIN, CATO T. · 2012 to 2013
$427k
NIAMS NIH HHS DP1 AR068147NIAMS NIH HHS R01 AR063698NIAMS NIH HHS R21 AR062771
6 · The paper itself

Abstract

The Holy Grail to address the clinical grand challenge of human limb loss is to develop innovative strategies to regrow the amputated limb. The remarkable advances in the scientific understanding of regeneration, stem cell science, material science and engineering, physics and novel surgical approaches in the past few decades have provided a regenerative tool box to face this grand challenge and address the limitations of human wound healing. Here we discuss the convergence approach put forward by the field of Regenerative Engineering to use the regenerative tool box to design and develop novel translational strategies to limb regeneration.

Indexed as

advanced biomaterial scienceclinical translationlimb regenerationregenerative engineeringstem cells

Identifiers

PMID27047679
PMCPMC4817321

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.