ReviewRegenerative biomaterials2016
Future challenges in the in vitro and in vivo evaluation of biomaterial biocompatibility.
Review in Regenerative biomaterials, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 124 citations in OpenAlex.
- From bone replacement to regeneration. A biomaterials started journey.Materials today. Bio · 2026Review
- Targeting Intratumoral Bacteria for Enhanced Tumor Suppression with Nano-Based Therapeutics: A Scoping Review.Pharmaceutics · 2026Review
- Impact of two different hesperidin forms loaded on nanoscale modified borate bioglass scaffolds on rat critical-sized calvarial defects.Scientific reports · 2026Article
- Foreign body reaction: towards a macrophage-centered adverse outcome pathway for fibrotic encapsulation.Frontiers in toxicology · 2026Article
- Bioartificial human corneas generated by tissue engineering. A historical and technical review.Histology and histopathology · 2026Review
- In Vitro Cytotoxicity Evaluation of Nanosized Hydroxyapatite and Fluorapatite on Cell Lines and Their Relevance to the Alveolar Augmentation Process.Journal of functional biomaterials · 2025Article
- A comprehensive analysis of two types of xenogeneic bone particles for use in maxillofacial bone regeneration therapies.PloS one · 2025Article
- Article
- Research Progress on Laser Powder Bed Fusion Additive Manufacturing of Zinc Alloys.Materials (Basel, Switzerland) · 2024Review
- Practical Guidance for Clinical Microbiology Laboratories: Microbiologic diagnosis of implant-associated infections.Clinical microbiology reviews · 2024Review
- Nylons with Applications in Energy Generators, 3D Printing and Biomedicine.Molecules (Basel, Switzerland) · 2024Review
- Characterization of hFOB 1.19 Cell Line for Studying Zn-Based Degradable Metallic Biomaterials.Materials (Basel, Switzerland) · 2024Article
- Development of Poly(sorbitol adipate)-Gels (Basel, Switzerland) · 2023Article
- Surface grafting of polymeric catheters and stents to prevent biofilm formation of pathogenic bacteria.Journal, genetic engineering & biotechnology · 2023Article
- Nanotherapeutics with immunoregulatory functions for the treatment of bacterial infection.Biomaterials research · 2023Review
- Influence of a Physiologically Formed Blood Clot on Pre-Osteoblastic Cells Grown on a BMP-7-Coated Nanoporous Titanium Surface.Biomimetics (Basel, Switzerland) · 2023Article
- In Vivo Biofilm Formation on Novel PEEK, Titanium, and Zirconia Implant Abutment Materials.International journal of molecular sciences · 2023Article
- Superstable homogeneous lipiodol-ICG formulation: initial feasibility and first-in-human clinical application for ruptured hepatocellular carcinoma.Regenerative biomaterials · 2023Article
- Advanced strategies to thwart foreign body response to implantable devices.Bioengineering & translational medicine · 2022Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As the science and engineering of biomaterials continues to expand with increased emphasis on the development of nanomaterials and tissue engineering scaffolds, emphasis also must be placed on appropriate and adequate approaches to the in vivo and in vitro evaluation of biomaterial biocompatibility/biological response evaluation. This article presents six topic areas that should be addressed by investigators as they move forward in the development of new systems for regenerative medicine. Most certainly, there are other areas that require attention to detail and a more complete understanding of the strengths and weaknesses of various experimental approaches to biomaterial/biological response evaluation. The small number of issues addressed in this article is only meant to bring to the attention of prospective investigators and authors, the importance of the development of adequate and appropriate evaluation techniques that address the unique features of biomaterials utilized in the development of new medical devices.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.