ArticleInternational journal of hematology-oncology and stem cell research2016
A survey on the relationship between serum 25-hydroxy vitamin D level and tumor characteristics in patients with breast cancer.
Article in International journal of hematology-oncology and stem cell research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The trial behind it
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Who cites it
8 citing papers in PubMed, 18 citations in OpenAlex.
- Serum 25-Hydroxyvitamin D Levels in Breast Cancer Patients: A Cross-Sectional Analysis by Molecular Tumor Subtypes.Journal of clinical medicine · 2026Article
- Vitamin D and Its Metabolites Status before and during Chemotherapy in Caucasian Breast Cancer Patients.Metabolites · 2023Article
- Vitamin D and breast cancer risk: A systematic review and meta-analysis in Iranian patients.Annals of medicine and surgery (2012) · 2022Review
- Vitamin D, Th17 Lymphocytes, and Breast Cancer.Cancers · 2022Review
- Vitamin D deficiency and tumor aggressiveness in gastroenteropancreatic neuroendocrine tumors.Endocrine · 2022Article
- Association between serum Vitamin D levels and prognostic factors in nonmetastatic breast cancer patients.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2022Article
- Association between pre-chemotherapy serum levels of vitamin D and clinicopathologic findings in gastric cancer.Caspian journal of internal medicine · 2020Article
- Vitamin D and Breast Cancer: Latest Evidence and Future Steps.Breast cancer : basic and clinical research · 2017Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn recent years, epidemiologic and laboratory studies have implied that vitamin D deficiency has a role in the pathogenesis of breast cancer. It has shown that vitamin D can prevent tumor progression induced by carcinogens and inhibit the carcinogenic effects of high fat diet on breast tissue and growth of tumor cells. This study aimed to evaluate serum 25-hydroxyvitamin D level and its role in relation to tumor characteristics and different stages of disease in women with breast cancer. SUBJECT AND
methodsThis is a cross-sectional study on 200 patients with breast cancer at different stages of the disease. Information on age, menstrual status, BMI and tumor characteristics were recorded. Serum 25-hydroxy vitamin D concentrations were measured by radioimmunoassay (RIA). Mean and standard deviation were used to describe the data. Meanwhile, T-test and sum of squares test were used to analyze the data. P<0.05 was considered significant.
resultsAmong 200 patients, 47 (23.5%) had severe vitamin D deficiency, 75 (37.5 %) had mild vitamin D deficiency and 78 (39.0 %) had sufficient vitamin D levels. There was a significant correlation between low vitamin D levels and advanced stage of breast cancer, particularly in postmenopausal patients.
conclusionIt seems that lower levels of vitamin D accompany worse clinicopathologic features. Thus, treatment of vitamin D deficiency in postmenopausal patients might be of great benefits.
Indexed as
Identifiers
27047648PMC4818786W2339768837What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.