ArticleFrontiers in plant science2016
Identification and Comparative Analysis of H2O2-Scavenging Enzymes (Ascorbate Peroxidase and Glutathione Peroxidase) in Selected Plants Employing Bioinformatics Approaches.
Article in Frontiers in plant science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.
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Who cites it
68 citing papers in PubMed, 195 citations in OpenAlex.
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- Comparative analysis of synteny and functional divergence of APX genes in Fragaria vesca and Fragaria×ananassa.BMC plant biology · 2025Article
- Transcriptome analysis of sugar beet in response to the pathogenic oomycete Aphanomyces cochlioides.BMC plant biology · 2024Article
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- Nuclear integration of MYB36 and APX-1 genes impart heat tolerance in wheat.Functional & integrative genomics · 2024Article
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- Growth and Physiological Responses of Magnoliaceae to NaCl Stress.Plants (Basel, Switzerland) · 2024Article
- Uncovering the Role of Hormones in Enhancing Antioxidant Defense Systems in Stressed Tomato (Plants (Basel, Switzerland) · 2023Review
- Reactive Oxygen Species in Drought-Induced Stomatal Closure: The Potential Roles of NPR1.Plants (Basel, Switzerland) · 2023Article
- Genome-Wide Analysis and Expression Profiling of the Glutathione Peroxidase-like Enzyme Gene Family inInternational journal of molecular sciences · 2023Article
- Genome-Wide Identification and Analysis of the Hsp40/J-Protein Family Reveals Its Role in Soybean (Genes · 2023Article
8 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Among major reactive oxygen species (ROS), hydrogen peroxide (H2O2) exhibits dual roles in plant metabolism. Low levels of H2O2 modulate many biological/physiological processes in plants; whereas, its high level can cause damage to cell structures, having severe consequences. Thus, steady-state level of cellular H2O2 must be tightly regulated. Glutathione peroxidases (GPX) and ascorbate peroxidase (APX) are two major ROS-scavenging enzymes which catalyze the reduction of H2O2 in order to prevent potential H2O2-derived cellular damage. Employing bioinformatics approaches, this study presents a comparative evaluation of both GPX and APX in 18 different plant species, and provides valuable insights into the nature and complex regulation of these enzymes. Herein, (a) potential GPX and APX genes/proteins from 18 different plant species were identified, (b) their exon/intron organization were analyzed, (c) detailed information about their physicochemical properties were provided, (d) conserved motif signatures of GPX and APX were identified, (e) their phylogenetic trees and 3D models were constructed, (f) protein-protein interaction networks were generated, and finally (g) GPX and APX gene expression profiles were analyzed. Study outcomes enlightened GPX and APX as major H2O2-scavenging enzymes at their structural and functional levels, which could be used in future studies in the current direction.
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