Evidence map›Paper›PMID 27047443›Full record

ReviewFrontiers in neurology2016

Embolic Strokes of Unknown Source and Cryptogenic Stroke: Implications in Clinical Practice.

Amre Nouh, Mohammed Hussain, Tapan Mehta, Shadi Yaghi

Abstract readReview
In one paragraph

Review in Frontiers in neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  16. Article
  17. Aortic Sources of Embolism.Frontiers in neurology · 2020
    Review
  18. Article
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Amre NouhHartford Hospital, University of Connecticut , Hartford, CT , USA.
Mohammed HussainHartford Hospital, University of Connecticut , Hartford, CT , USA.
Tapan MehtaHartford Hospital, University of Connecticut , Hartford, CT , USA.
Shadi YaghiBrown University , Providence, RI , USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Up to a third of strokes are rendered cryptogenic or of undetermined etiology. This number is specifically higher in younger patients. At times, inadequate diagnostic workups, multiple causes, or an under-recognized etiology contributes to this statistic. Embolic stroke of undetermined source, a new clinical entity particularly refers to patients with embolic stroke for whom the etiology of embolism remains unidentified despite through investigations ruling out established cardiac and vascular sources. In this article, we review current classification and discuss important clinical considerations in these patients; highlighting cardiac arrhythmias and structural abnormalities, patent foramen ovale, paradoxical sources, and potentially under-recognized, vascular, inflammatory, autoimmune, and hematologic sources in relation to clinical practice.

Indexed as

aortic arch atherosclerosiscardiac monitoringcryptogenic strokeembolic stroke of undetermined sourcehypercoagulable stateparoxysmal atrial fibrillationpatent foramen ovale

Identifiers

PMID27047443
PMCPMC4800279

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.