ArticleFrontiers in psychiatry2016
A Closer Look at the Effects of Repeated Cocaine Exposure on Adaptive Decision-Making under Conditions That Promote Goal-Directed Control.
Article in Frontiers in psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Modeling impaired insight after drug use in rodents.Behavioral neuroscience · 2024Review
- Differential effects of acute and prolonged morphine withdrawal on motivational and goal-directed control over reward-seeking behaviour.Addiction biology · 2024Article
- Neither Amphetamine nor Sub-Anesthetic Ketamine Treatment during Adolescence Impairs Devaluation in Rats Tested during Adulthood.Journal of integrative neuroscience · 2024Article
- Differential effects of acute and prolonged morphine withdrawal on motivational and goal-directed control over reward-seeking behavior.bioRxiv : the preprint server for biology · 2023Article
- Drug reinforcement impairs cognitive flexibility by inhibiting striatal cholinergic neurons.Nature communications · 2023Article
- Long-term effects of THC exposure on reward learning and motivated behavior in adolescent and adult male rats.Psychopharmacology · 2023Article
- On the interrelation between alcohol addiction-like behaviors in rats.Psychopharmacology · 2022Article
- Habit, choice, and addiction.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Review
- Computational models of drug use and addiction: A review.Journal of abnormal psychology · 2020Review
- Fractionating the all-or-nothing definition of goal-directed and habitual decision-making.Journal of neuroscience research · 2020Review
- Addiction is driven by excessive goal-directed drug choice under negative affect: translational critique of habit and compulsion theory.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Review
- Habitual Preference for the Nondrug Reward in a Drug Choice Setting.Frontiers in behavioral neuroscience · 2020Article
- A ketogenic diet diminishes behavioral responses to cocaine in young adult male and female rats.Neuropharmacology · 2019Article
- Inflexible habitual decision-making during choice between cocaine and a nondrug alternative.Translational psychiatry · 2019Article
- Behavioral and neural mechanisms underlying habitual and compulsive drug seeking.Progress in neuro-psychopharmacology & biological psychiatry · 2018Review
- The impact of drugs of abuse on executive function: characterizing long-term changes in neural correlates following chronic drug exposure and withdrawal in rats.Learning & memory (Cold Spring Harbor, N.Y.) · 2018Review
- Are Cocaine-Seeking "Habits" Necessary for the Development of Addiction-Like Behavior in Rats?The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Habitual nicotine-seeking in rats following limited training.Psychopharmacology · 2017Article
- Prior Cocaine Self-Administration Increases Response-Outcome Encoding That Is Divorced from Actions Selected in Dorsal Lateral Striatum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Pathological Overeating: Emerging Evidence for a Compulsivity Construct.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
It has been proposed that compulsive drug seeking reflects an underlying dysregulation in adaptive behavior that favors habitual (automatic and inflexible) over goal-directed (deliberative and highly flexible) action selection. Rodent studies have established that repeated exposure to cocaine or amphetamine facilitates the development of habits, producing behavior that becomes unusually insensitive to a reduction in the value of its outcome. The current study more directly investigated the effects of cocaine pre-exposure on goal-directed learning and action selection using an approach that discourages habitual performance. After undergoing a 15-day series of cocaine (15 or 30 mg/kg, i.p.) or saline injections and a drug withdrawal period, rats were trained to perform two different lever-press actions for distinct reward options. During a subsequent outcome devaluation test, both cocaine- and saline-treated rats showed a robust bias in their choice between the two actions, preferring whichever action had been trained with the reward that retained its value. Thus, it appears that the tendency for repeated cocaine exposure to promote habit formation does not extend to a more complex behavioral scenario that encourages goal-directed control. To further explore this issue, we assessed how prior cocaine treatment would affect the rats' ability to learn about a selective reduction in the predictive relationship between one of the two actions and its outcome, which is another fundamental feature of goal-directed behavior. Interestingly, we found that cocaine-treated rats showed enhanced, rather than diminished, sensitivity to this action-outcome contingency degradation manipulation. Given their mutual dependence on striatal dopamine signaling, we suggest that cocaine's effects on habit formation and contingency learning may stem from a common adaptation in this neurochemical system.
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