ArticleFrontiers in behavioral neuroscience2016
Prolonged Consumption of Sucrose in a Binge-Like Manner, Alters the Morphology of Medium Spiny Neurons in the Nucleus Accumbens Shell.
Article in Frontiers in behavioral neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 50 citations in OpenAlex.
- Insulin sensitivity in mesolimbic pathways predicts and improves with weight loss in older dieters.eLife · 2022Trial
- Dendritic morphology of motor neurons and interneurons within the compact, semicompact, and loose formations of the rat nucleus ambiguus.Frontiers in cellular neuroscience · 2024Article
- Orbitofrontal intronic circular RNA from Nrxn3 mediates reward learning and motivation for reward.Progress in neurobiology · 2024Article
- α-MSH-catabolic enzyme prolylcarboxypeptidase in nucleus accumbens shell ameliorates stress susceptibility in mice through regulating synaptic plasticity.Acta pharmacologica Sinica · 2023Article
- Neurotrophic Factors and Dendritic Spines.Advances in neurobiology · 2023Article
- Investigating the Role of GABA in Neural Development and Disease Using Mice Lacking GAD67 or VGAT Genes.International journal of molecular sciences · 2022Review
- A High-Sugar Diet Consumption, Metabolism and Health Impacts with a Focus on the Development of Substance Use Disorder: A Narrative Review.Nutrients · 2022Review
- Genetics and neurobiology of eating disorders.Nature neuroscience · 2022Review
- Long-Term Overconsumption of Sugar Starting at Adolescence Produces Persistent Hyperactivity and Neurocognitive Deficits in Adulthood.Frontiers in neuroscience · 2021Article
- Excessive Consumption of Sugar: an Insatiable Drive for Reward.Current nutrition reports · 2019Review
- Mesolimbic white matter connectivity mediates the preference for sweet food.Scientific reports · 2019Article
- Altered Activity of SK Channel Underpins Morphine Withdrawal Relevant Psychiatric Deficiency in Infralimbic to Accumbens Shell Pathway.Frontiers in psychiatry · 2019Article
- High-Salt Exposure During Perinatal Development Enhances Stress Sensitivity.Developmental neurobiology · 2018Article
- Complex housing causes a robust increase in dendritic complexity and spine density of medial prefrontal cortical neurons.Scientific reports · 2018Article
- Sex Specific Alterations in α4*Nicotinic Receptor Expression in the Nucleus Accumbens.Brain sciences · 2018Article
- Sugar Addiction: From Evolution to Revolution.Frontiers in psychiatry · 2018Review
- Article
- Social and environmental enrichment has different effects on ethanol and sucrose consumption in mice.Brain and behavior · 2017Article
- A Rat Drinking in the Dark Model for Studying Ethanol and Sucrose Consumption.Frontiers in behavioral neuroscience · 2017Article
- Motor Areas Show Altered Dendritic Structure in an Amyotrophic Lateral Sclerosis Mouse Model.Frontiers in neuroscience · 2017Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The modern diet has become highly sweetened, resulting in unprecedented levels of sugar consumption, particularly among adolescents. While chronic long-term sugar intake is known to contribute to the development of metabolic disorders including obesity and type II diabetes, little is known regarding the direct consequences of long-term, binge-like sugar consumption on the brain. Because sugar can cause the release of dopamine in the nucleus accumbens (NAc) similarly to drugs of abuse, we investigated changes in the morphology of neurons in this brain region following short- (4 weeks) and long-term (12 weeks) binge-like sucrose consumption using an intermittent two-bottle choice paradigm. We used Golgi-Cox staining to impregnate medium spiny neurons (MSNs) from the NAc core and shell of short- and long-term sucrose consuming rats and compared these to age-matched water controls. We show that prolonged binge-like sucrose consumption significantly decreased the total dendritic length of NAc shell MSNs compared to age-matched control rats. We also found that the restructuring of these neurons resulted primarily from reduced distal dendritic complexity. Conversely, we observed increased spine densities at the distal branch orders of NAc shell MSNs from long-term sucrose consuming rats. Combined, these results highlight the neuronal effects of prolonged binge-like intake of sucrose on NAc shell MSN morphology.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.