ArticleFrontiers in neuroanatomy2016
Whole Brain Imaging with Serial Two-Photon Tomography.
Article in Frontiers in neuroanatomy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed.
- Macrostructural, microstructural, and cellular effects of neuroinflammation on the mouse brain.Brain, behavior, & immunity - health · 2026Article
- Glomeruli of the Mouse Olfactory Bulb: Numbers, Sizes, Shapes.The European journal of neuroscience · 2025Article
- Mid-Infrared Photothermal Mesoscopy with Millimeter Field of View and Sub-micron Spatial Resolution.bioRxiv : the preprint server for biology · 2025Article
- Validation of structure tensor analysis for orientation estimation in brain tissue microscopy.Journal of neuroscience methods · 2025Article
- Delivery of a fibrin-binding hemostatic polymer ameliorates neurovascular damage and neural tissue loss after traumatic brain injury.Science advances · 2025Article
- SlicesMapi: An Interactive Three-Dimensional Registration Method for Serial Histological Brain Slices.Neuroinformatics · 2025Article
- Validation of Structure Tensor Analysis for Orientation Estimation in Brain Tissue Microscopy.bioRxiv : the preprint server for biology · 2025Article
- An extended and improved CCFv3 annotation and Nissl atlas of the entire mouse brain.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Article
- Subdiffraction Imaging of Cleared and Expanded Large-Scale Tissues.Chemical & biomedical imaging · 2024Review
- Analyzing Thalamocortical Tract-Tracing Experiments in a Common Reference Space.Neuroinformatics · 2024Article
- DeepSlice: rapid fully automatic registration of mouse brain imaging to a volumetric atlas.Nature communications · 2023Article
- Review
- Deep ultraviolet fluorescence microscopy of three-dimensional structures in the mouse brain.Scientific reports · 2023Article
- Sex, strain, and lateral differences in brain cytoarchitecture across a large mouse population.eLife · 2023Article
- Article
- Advances in studying whole mouse brain vasculature using high-resolution 3D light microscopy imaging.Neurophotonics · 2022Review
- Automated computation of nerve fibre inclinations from 3D polarised light imaging measurements of brain tissue.Scientific reports · 2022Article
- Advanced high resolution three-dimensional imaging to visualize the cerebral neurovascular network in stroke.International journal of biological sciences · 2022Review
- Fluorescent transgenic mouse models for whole-brain imaging in health and disease.Frontiers in molecular neuroscience · 2022Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Imaging entire mouse brains at submicron resolution has historically been a challenging undertaking and largely confined to the province of dedicated atlasing initiatives. This has limited systematic investigations into important areas of neuroscience, such as neural circuits, brain mapping and neurodegeneration. In this article, we describe in detail Serial Two-Photon (STP) tomography, a robust, reliable method for imaging entire brains with histological detail. We provide examples of how the basic methodology can be extended to other imaging modalities, such as Optical Coherence Tomography (OCT), in order to provide unique contrast mechanisms. Furthermore, we provide a survey of the research that STP tomography has enabled in the field of neuroscience, provide examples of how this technology enables quantitative whole brain studies, and discuss the current limitations of STP tomography-based approaches.
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Registered trials
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