ReviewFrontiers in neuroscience2016
Mosaic Subventricular Origins of Forebrain Oligodendrogenesis.
Review in Frontiers in neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Embracing the heterogeneity of neural stem cells in the subventricular zone.Stem cell reports · 2025Article
- Neural stem cells of the subventricular zone: A potential stem cell pool for brain repair in Parkinson's disease.Stem cell reports · 2025Review
- Neural stem cell relay from B1 to B2 cells in the adult mouse ventricular-subventricular zone.Cell reports · 2025Article
- Deubiquitinase Mysm1 regulates neural stem cell proliferation and differentiation by controlling Id4 expression.Cell death & disease · 2024Article
- Induction of Nanog in neural progenitor cells for adaptive regeneration of ischemic brain.Experimental & molecular medicine · 2022Article
- Review
- Molecular and functional heterogeneity in dorsal and ventral oligodendrocyte progenitor cells of the mouse forebrain in response to DNA damage.Nature communications · 2022Article
- Drug connectivity mapping and functional analysis reveal therapeutic small molecules that differentially modulate myelination.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022Article
- Gender-specific effects of transthyretin on neural stem cell fate in the subventricular zone of the adult mouse.Scientific reports · 2019Article
- Insights into ligand expression heterogeneity across multiple cell types in the adult forebrain that regulates neural stem cell behavior.Neural regeneration research · 2019Article
- HOPX Defines Heterogeneity of Postnatal Subventricular Zone Neural Stem Cells.Stem cell reports · 2018Article
- Transcriptional Profiling of Ligand Expression in Cell Specific Populations of the Adult Mouse Forebrain That Regulates Neurogenesis.Frontiers in neuroscience · 2018Article
- Embracing oligodendrocyte diversity in the context of perinatal injury.Neural regeneration research · 2017Review
- Article
- Pharmacogenomic identification of small molecules for lineage specific manipulation of subventricular zone germinal activity.PLoS biology · 2017Article
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Authors and funding
3 authors.
Funding
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Abstract
In the perinatal as well as the adult CNS, the subventricular zone (SVZ) of the forebrain is the largest and most active source of neural stem cells (NSCs) that generates neurons and oligodendrocytes (OLs), the myelin forming cells of the CNS. Recent advances in the field are beginning to shed light regarding SVZ heterogeneity, with the existence of spatially segregated microdomains that are intrinsically biased to generate phenotypically distinct neuronal populations. Although most research has focused on this regionalization in the context of neurogenesis, newer findings underline that this also applies for the genesis of OLs under the control of specific patterning molecules. In this mini review, we discuss the origins as well as the mechanisms that induce and maintain SVZ regionalization. These come in the flavor of specific signaling ligands and subsequent initiation of transcriptional networks that provide a basis for subdividing the SVZ into distinct lineage-specific microdomains. We further emphasize canonical Wnts and FGF2 as essential signaling pathways for the regional genesis of OL progenitors from NSCs of the dorsal SVZ. This aspect of NSC biology, which has so far received little attention, may unveil new avenues for appropriately recruiting NSCs in demyelinating diseases.
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