Evidence map›Paper›PMID 27047251›Full record

ArticleCurrent genomics2015

Circular RNAs in Eukaryotic Cells.

Liang Chen, Chuan Huang, Xiaolin Wang, Ge Shan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current genomics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers.

0numbers the graph read from it
0cells of the map it votes in
87citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

87 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Circular RNAs in Liver Diseases.Advances in experimental medicine and biology · 2025
    Review
  8. Review
  9. Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. Review
  15. Review
  16. Circular RNAs: Promising Targets in Osteoporosis.Current osteoporosis reports · 2023
    Review
  17. Article
  18. Article
  19. AnIranian journal of basic medical sciences · 2023
    Article
  20. circRNA, a novel diagnostic biomarker for coronary heart disease.Frontiers in cardiovascular medicine · 2023
    Article

27 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Liang ChenSchool of Life Sciences & CAS Key Laboratory of Brain Function and Disease, University of Science and Technology of China, Hefei, Anhui Province 230027, P.R. China.
Chuan HuangSchool of Life Sciences & CAS Key Laboratory of Brain Function and Disease, University of Science and Technology of China, Hefei, Anhui Province 230027, P.R. China.
Xiaolin WangSchool of Life Sciences & CAS Key Laboratory of Brain Function and Disease, University of Science and Technology of China, Hefei, Anhui Province 230027, P.R. China.
Ge ShanSchool of Life Sciences & CAS Key Laboratory of Brain Function and Disease, University of Science and Technology of China, Hefei, Anhui Province 230027, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circular RNAs (circRNAs) are now recognized as large species of transcripts in eukaryotic cells. From model organisms such as C. elegans, Drosophila, mice to human beings, thousands of circRNAs formed from back-splicing of exons have been identified. The known complexity of transcriptome has been greatly expanded upon the discovery of these RNAs. Studies about the biogenesis and physiological functions have yielded substantial knowledge for the circRNAs, and they are now more likely to be viewed as regulatory elements coded by the genome rather than unavoidable noise of gene expression. Certain human diseases may also relate to circRNAs. These circRNAs show diversifications in features such as sequence composition and cellular localization, and thus we propose that they may be divided into subtypes such as cytoplasmic circRNAs, nuclear circRNAs, and exon-intron circRNAs (EIciRNAs). Here we summarize and discuss knowns and unknowns for these RNAs, and we need to keep in mind that the whole field is still at the beginning of exciting explorations.

Indexed as

BiogenesiscircRNAEIciRNAmicroRNAmicroRNA spongencRNATranscription.

Identifiers

PMID27047251
PMCPMC4763969

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.