Evidence map›Paper›PMID 27047227›Full record

ArticleJournal of orthopaedics2015

NELL-1 expression in tumors of cartilage.

Jia Shen, Gregory LaChaud, Swati Shrestha, Greg Asatrian, Xinli Zhang, Sarah M Dry, Chia Soo, Kang Ting, Aaron W James

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of orthopaedics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

  1. NELL-1: role and mechanisms in disease pathogenesis and development.Frontiers in cell and developmental biology · 2026
    Review
  2. Role of NEL‑like molecule‑1 in osteogenesis/chondrogenesis (Review).International journal of molecular medicine · 2025
    Review
  3. Article
  4. Review
  5. Biomarkers of chondrosarcoma.Journal of clinical pathology · 2018
    Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Jia ShenDivision of Growth and Development and Section of Orthodontics, School of Dentistry UCLA, Los Angeles, CA 90095, United States; Department of Pathology and Laboratory Medicine, UCLA, Los Angeles, CA 90095, United States.
Gregory LaChaudDivision of Growth and Development and Section of Orthodontics, School of Dentistry UCLA, Los Angeles, CA 90095, United States; Department of Pathology and Laboratory Medicine, UCLA, Los Angeles, CA 90095, United States; Vanderbilt University School of Medicine, Nashville, TN 37212, United States.
Swati ShresthaDivision of Growth and Development and Section of Orthodontics, School of Dentistry UCLA, Los Angeles, CA 90095, United States; Department of Pathology and Laboratory Medicine, UCLA, Los Angeles, CA 90095, United States.
Greg AsatrianDivision of Growth and Development and Section of Orthodontics, School of Dentistry UCLA, Los Angeles, CA 90095, United States; Department of Pathology and Laboratory Medicine, UCLA, Los Angeles, CA 90095, United States.
Xinli ZhangDivision of Growth and Development and Section of Orthodontics, School of Dentistry UCLA, Los Angeles, CA 90095, United States.
Sarah M DryDepartment of Pathology and Laboratory Medicine, UCLA, Los Angeles, CA 90095, United States.
Chia SooDivision of Plastic and Reconstructive Surgery, Department of Surgery, UCLA, Los Angeles, CA 90095, United States; UCLA and Orthopaedic Hospital, Department of Orthopaedic Surgery and the Orthopaedic Hospital Research Center, Los Angeles, CA 90095, United States.
Kang TingDivision of Growth and Development and Section of Orthodontics, School of Dentistry UCLA, Los Angeles, CA 90095, United States.
Aaron W JamesDivision of Growth and Development and Section of Orthodontics, School of Dentistry UCLA, Los Angeles, CA 90095, United States; Department of Pathology and Laboratory Medicine, UCLA, Los Angeles, CA 90095, United States; UCLA and Orthopaedic Hospital, Department of Orthopaedic Surgery and the Orthopaedic Hospital Research Center, Los Angeles, CA 90095, United States; David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, United States.
University of California, Los Angeles · USOrthopaedic Hospital · USVanderbilt University · US

Funding

NELL-1's functional role in cartilage regenerationR01AR068835 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EASLEY, JEREMIAH, SOO, CHIA · 2015 to 2019
$2.2M
NELL-1 Systemic Therapy for OsteoporosisR01AR066782 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EASLEY, JEREMIAH, TING, KANG · 2014 to 2018
$2.0M
NIAMS NIH HHS R01 AR066782NIAMS NIH HHS R01 AR068835
6 · The paper itself

Abstract

BACKGROUND/

aimsNELL-1 is a novel osteochondral differentiation factor protein with increasing usage in tissue engineering. Previously, we reported the expression patterns of NELL-1 in bone-forming skeletal tumors. With increasing interest in the use of NELL-1 protein, we sought to examine the expression of NELL-1 in cartilage-forming tumors.

methodsImmunohistochemical expression was examined in human pathologic specimens.

resultsConsistent NELL-1 overexpression across all cartilage-forming tumors was observed. Similar degrees of expression were observed in enchondroma, chondrosarcoma, and chondroblastic osteosarcoma. NELL-1 expression did not significantly vary by tumor grade.

conclusionIn summary, NELL-1 demonstrates reliable and consistent expression across cartilage-forming skeletal tumors.

Indexed as

Chondroblastic osteosarcomaChondrosarcomaEnchondromaNell-1Osteosarcoma

Identifiers

PMID27047227
PMCPMC4796526
OpenAlexW2208848231

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.