ArticleJournal of orthopaedics2015
Articular cartilage and local anaesthetic: A systematic review of the current literature.
Article in Journal of orthopaedics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Analgesic effect and safety of single-dose intra-articular magnesium after arthroscopic surgery: a systematic review and meta-analysis.Scientific reports · 2016Pooled it
- Updates in ultrasound-guided musculoskeletal interventions.The British journal of radiology · 2026Review
- Prolotherapy in the Treatment of Knee Osteoarthritis: How to Perform.Arthroscopy techniques · 2026Article
- Pharmacological Agents for Soft Tissue and Articular Injections: From Mechanisms to Clinical Applications.Journal of clinical medicine · 2026Review
- Adverse events associated with local anaesthetic use in musculoskeletal injection therapy: a scoping review.BMJ open sport & exercise medicine · 2026Article
- Lidocaine Shows Significant Antimicrobial Effects AgainstBiomedicines · 2025Article
- The Potency of Cytotoxic Mechanisms of Local Anesthetics in Human Chondrocyte Cells.International journal of molecular sciences · 2024Article
- Advanced Non-Operative Interventions for Anterior Knee Pain.Current reviews in musculoskeletal medicine · 2024Review
- Fast treatment of anterior shoulder dislocations with two sedation-free methods: The Davos self-reduction method and Arlt method.Shoulder & elbow · 2024Article
- The In Vivo Chondrotoxicity of Single Intra-articular Injection of Local Anesthetic in Rat Cartilage.Cureus · 2024Article
- Efficacy of Intra-articular Versus Extra-articular Bupivacaine Injection in Arthroscopic Partial Meniscectomy: A Prospective, Randomized, Double-Blind Clinical Trial.Orthopaedic journal of sports medicine · 2023Article
- Management of Patients with Adhesive Capsulitis via Ultrasound-Guided Hydrodilatation without Concomitant Intra-Articular Lidocaine Infusion: A Single-Center Experience.Life (Basel, Switzerland) · 2022Article
- Dexamethasone Does not Compensate for Local Anesthetic Cytotoxic Effects on Tenocytes: Morphine or Morphine Plus Dexamethasone May Be a Safe Alternative.Arthroscopy, sports medicine, and rehabilitation · 2022Article
- Minimally invasive arthroscopy of the knee using a new 2 mm device.Clinical case reports · 2022Article
- Article
- Predicting outcomes in patients undergoing intra-articular corticosteroid hip injections.Skeletal radiology · 2021Article
- Toxicity of tranexamic acid (TXA) to intra-articular tissue in orthopaedic surgery: a scoping review.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2021Article
- Intra-articular Morphine and Ropivacaine Injection Provides Efficacious Analgesia As Compared With Femoral Nerve Block in the First 24 Hours After ACL Reconstruction: Results From a Bone-Patellar Tendon-Bone Graft in an Adolescent Population.Orthopaedic journal of sports medicine · 2021Article
- Comparison ofFrontiers in pain research (Lausanne, Switzerland) · 2021Review
- Clinical Pharmacokinetics and Pharmacodynamics of Levobupivacaine.Clinical pharmacokinetics · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChondrolysis involves the breakdown of cartilage following arthroscopic surgery, most commonly affecting the glenohumeral joint.
methodsThis review summarises all clinical and laboratory studies regarding local anaesthetic (LA) and its association with chondrolysis. We identified 289 papers, 41 of which met our inclusion criteria and were included in the final review.
resultsBupivacaine, lidocaine, ropivacaine and levobupivacaine are all toxic to cartilage. Intra-articular infusions confer a greater toxicity to cartilage than single injections.
conclusionsIntra-articular LA pain pumps carry a high risk of chondrolysis and should be avoided. Further studies are indicated to assess long-term single exposure LA implications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.