Evidence map›Paper›PMID 27046848›Full record

ArticleIEEE transactions on ultrasonics, ferroelectrics, and frequency control2016

On the Quantitative Potential of Viscoelastic Response (VisR) Ultrasound Using the One-Dimensional Mass-Spring-Damper Model.

Mallory R Selzo, Christopher J Moore, Md Murad Hossain, Mark L Palmeri, Caterina M Gallippi

Erratum issuedAbstract read
In one paragraph

Article in IEEE transactions on ultrasonics, ferroelectrics, and frequency control, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 58 citations in OpenAlex.

  1. Article
  2. Surface Compression Alters in Vivo VisR Stiffness, Viscosity, and Anisotropy Measurements in Human Breast.IEEE open journal of ultrasonics, ferroelectrics, and frequency control · 2025
    Article
  3. VisR Ultrasound Improves Diagnosis of Breast Cancer by the Elastogram-to-B-Mode Ratio in a Blinded Reader Study.IEEE open journal of ultrasonics, ferroelectrics, and frequency control · 2025
    Article
  4. Article
  5. Quantitative Viscoelastic Response (QVisR): Direct Estimation of Viscoelasticity With Neural Networks.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2024
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Local Phase Velocity Based Imaging of Viscoelastic Phantoms and Tissues.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2021
    Article
  17. Article
  18. Hydrophone Spatial Averaging Artifacts for ARFI Beams from Array Transducers.IEEE International Ultrasonics Symposium : [proceedings]. IEEE International Ultrasonics Symposium · 2020
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Mallory R Selzo
Christopher J Moore
Md Murad Hossain
Mark L Palmeri
Caterina M Gallippi
North Carolina State University · USDuke University · US

Funding

UNC BIRCWH CAREER DEVELOPMENT PROGRAMK12HD001441 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BOGGESS, KIM A · 2000 to 2019
$9.3M
Transcutaneous ARFI Ultrasound for Differentiating Carotid Plaque with High Stroke RiskR01HL092944 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GALLIPPI, CATERINA M · 2009 to 2022
$5.5M
VisR Ultrasound for Noninvasively Monitoring Renal Allograft HealthR01DK107740 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Caterina M Gallippi · 2016 to 2026
$5.2M
DP ARF Ultrasound for Monitoring Muscle Degeneration in Duchenne Muscular DystropR01NS074057 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GALLIPPI, CATERINA M · 2011 to 2015
$2.0M
Independent Scientist: ARFI and RWI Ultrasound for Improved Atherosclerosis ImagiK02HL105659 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GALLIPPI, CATERINA M · 2010 to 2014
$509k
UNC-Chapel Hill Integrated Biomedical Research Training ProgramT90DA022857 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MARZLUFF, WILLIAM F. · 2006 to 2009
$417k
NHLBI NIH HHS K02 HL105659NHLBI NIH HHS R01 HL092944NICHD NIH HHS K12 HD001441NIDA NIH HHS T90 DA022857NIDDK NIH HHS R01 DK107740NINDS NIH HHS R01 NS074057
6 · The paper itself

Abstract

Viscoelastic response (VisR) ultrasound is an acoustic radiation force (ARF)-based imaging method that fits induced displacements to a one-dimensional (1-D) mass-spring-damper (MSD) model to estimate the ratio of viscous to elastic moduli, τ, in viscoelastic materials. Error in VisR τ estimation arises from inertia and acoustic displacement underestimation. These error sources are herein evaluated using finite-element method (FEM) simulations, error correction methods are developed, and corrected VisR τ estimates are compared with true simulated τ values to assess VisR's relevance to quantifying viscoelasticity. With regard to inertia, adding a mass term in series with the Voigt model, to achieve the MSD model, accounts for inertia due to tissue mass when ideal point force excitations are used. However, when volumetric ARF excitations are applied, the induced complex system inertia is not described by the single-degree-of-freedom MSD model, causing VisR to overestimate τ. Regarding acoustic displacement underestimation, associated deformation of ARF-induced displacement profiles further distorts VisR τ estimates. However, median error in VisR τ is reduced to approximately -10% using empirically derived error correction functions applied to simulated viscoelastic materials with viscous and elastic properties representative of tissue. The feasibility of corrected VisR imaging is then demonstrated in vivo in the rectus femoris muscle of an adult with no known neuromuscular disorders. These results suggest VisR's potential relevance to quantifying viscoelastic properties clinically.

Indexed as

Elastic ModulusUltrasonographyViscosityAcousticsHumansMechanical Phenomena

Identifiers

PMID27046848
PMCPMC5016215
OpenAlexW2319161330

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.