ArticleDevelopmental biology2016
CACN-1 is required in the Caenorhabditis elegans somatic gonad for proper oocyte development.
Article in Developmental biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Sterility in the offspring ofmicroPublication biology · 2024Article
- Border cell polarity and collective migration require the spliceosome component Cactin.The Journal of cell biology · 2022Article
- Recent Advances in the Genetic, Anatomical, and Environmental Regulation of theJournal of developmental biology · 2020Review
- Functional Interactions BetweenG3 (Bethesda, Md.) · 2018Article
- Spectrin regulates cell contractility through production and maintenance of actin bundles in the Caenorhabditis elegans spermatheca.Molecular biology of the cell · 2018Article
- The DSL ligand APX-1 is required for normal ovulation in C. elegans.Developmental biology · 2018Article
- Regulating distal tip cell migration in space and time.Mechanisms of development · 2017Review
- Myosin activity drives actomyosin bundle formation and organization in contractile cells of theMolecular biology of the cell · 2017Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
CACN-1/Cactin is a conserved protein identified in a genome-wide screen for genes that regulate distal tip cell migration in the nematode Caenorhabditis elegans. In addition to possessing distal tip cells that migrate past their correct stopping point, animals depleted of cacn-1 are sterile. In this study, we show that CACN-1 is needed in the soma for proper germ line development and maturation. When CACN-1 is depleted, sheath cells are absent and/or abnormal. When sheath cells are absent, hermaphrodites produce sperm, but do not switch appropriately to oocyte production. When sheath cells are abnormal, some oocytes develop but are not successfully ovulated and undergo endomitotic reduplication (Emo). Our previous proteomic studies show that CACN-1 interacts with a network of splicing factors. Here, these interactors were screened using RNAi. Depletion of many of these factors led to missing or abnormal sheath cells and germ line defects, particularly absent and/or Emo oocytes. These results suggest CACN-1 is part of a protein network that influences somatic gonad development and function through alternative splicing or post-transcriptional gene regulation.
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Registered trials
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