Evidence map›Paper›PMID 27046475›Full record

ArticleSocial science & medicine (1982)2016

Medical mistrust among social network members may contribute to antiretroviral treatment nonadherence in African Americans living with HIV.

Laura M Bogart, Glenn J Wagner, Harold D Green, Matt G Mutchler, David J Klein, Bryce McDavitt, Sean J Lawrence, Charles L Hilliard

Registry-linked trialAbstract read
In one paragraph

Article in Social science & medicine (1982), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03331978 (A Randomized Controlled Trial of an Antiretroviral Treatment Adherence Intervention for HIV+ African Americans), which is not on this map. Cited by 58 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 1 pooled it
6.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03331978 nacompletednot on this mapstarted 2018, after this paper: background citation

A Randomized Controlled Trial of an Antiretroviral Treatment Adherence Intervention for HIV+ African Americans

TypeinterventionalSponsorRANDRan2018 to 2021Enrolled306ConditionsHIV/AIDSArmsRise - Treatment Education
3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 1 synthesis or guideline pooled it, 92 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Laura M BogartHealth Unit, RAND Corporation, Santa Monica, CA, USA. Electronic address: lbogart@rand.org.
Glenn J WagnerHealth Unit, RAND Corporation, Santa Monica, CA, USA.
Harold D GreenHealth Unit, RAND Corporation, Santa Monica, CA, USA.
Matt G MutchlerDepartment of Sociology, California State University, Dominguez Hills, CA, USA; Community-Based Research, AIDS Project Los Angeles, Los Angeles, CA, USA.
David J KleinHealth Unit, RAND Corporation, Santa Monica, CA, USA.
Bryce McDavittCommunity-Based Research, AIDS Project Los Angeles, Los Angeles, CA, USA; University of Southern California, Los Angeles, CA, USA.
Sean J LawrenceCommunity-Based Research, AIDS Project Los Angeles, Los Angeles, CA, USA.
Charles L HilliardCharles R. Drew University of Medicine and Science, Los Angeles, CA, USA.
RAND Corporation · USAPLA Health · USCharles R. Drew University of Medicine and Science · US

Funding

The impact of HIV viral diversity and cellular immunity on HIV pathogenesisP30AI060354 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI ROBERT A. PARKER · 2004 to 2026
$94.4M
Minority Populations Prevention Researcher TrainingR25HD045810 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NEILANDS, TORSTEN BRIAN · 2003 to 2018
$4.3M
Medical Mistrust, Social Networks, and Disparities in HIV Care Among BlacksR01MD003964 · NIMHD · BOSTON CHILDREN'S HOSPITAL · PI BOGART, LAURA M · 2009 to 2013
$2.0M
NIAID NIH HHS P30 AI060354NICHD NIH HHS R25 HD045810NIMHD NIH HHS R01 MD003964
6 · The paper itself

Abstract

rationaleAfrican Americans living with HIV are less likely to adhere to antiretroviral treatment (ART) compared to other racial/ethnic groups. Medical mistrust is thought to be a factor in this disparity.

objectiveWe examined (1) whether exposure to HIV conspiracy beliefs, a specific type of HIV-related mistrust (about the origins and treatment of HIV) in social networks is associated with ART nonadherence among African Americans living with HIV; and (2) the characteristics of individuals who discuss HIV-related mistrust in the social networks of African Americans living with HIV.

methodsAt baseline and 6- and 12-months post-baseline, 175 African Americans living with HIV on ART completed egocentric social network assessments, from which we assessed the structure and composition of their personal networks (the social context immediately surrounding them). HIV-related mistrust was operationalized with an indicator of whether any social network member had expressed HIV conspiracy beliefs to the participant. Daily medication adherence was monitored electronically.

resultsAt baseline, 63% of participants agreed with at least one conspiracy belief, and 55% reported hearing at least one social network member ("alter") express conspiracy beliefs. In a multivariate linear repeated measures regression, expression of conspiracy beliefs by similar others in the network (in terms of age, gender, HIV status, sexual orientation, and race/ethnicity) was associated with ART nonadherence (i.e., percentage of prescribed doses taken). In a multivariate logistic regression, expression of conspiracy beliefs was more likely among social network members who were HIV-positive, who knew the participants' serostatus, and with whom participants interacted frequently, and less likely among more well-connected social network members.

conclusionHIV-related mistrust in the network may be most influential when expressed by similar others who may be HIV-positive themselves.

Indexed as

Social SupportAdultAgedAnti-Retroviral AgentsBlack or African AmericanFemaleHIV InfectionsHumansLos AngelesMaleMiddle AgedSocioeconomic FactorsSurveys and QuestionnairesTreatment Adherence and ComplianceTrustAnti-Retroviral AgentsAfrican American/BlackConspiracy beliefsHIVMedical mistrustSocial networksTreatment adherence

Identifiers

PMID27046475
PMCPMC4981525
OpenAlexW2299552350

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.