ArticleAddiction biology2017
A prospective study of genetic factors, human laboratory phenotypes, and heavy drinking in late adolescence.
Article in Addiction biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
- Pharmacogenetic Effects of Naltrexone in Individuals of East Asian Descent: Human Laboratory Findings from a Randomized Trial.Alcoholism, clinical and experimental research · 2018Trial
- Drinking Motives Predict Subjective Effects of Alcohol and Alcohol Wanting and Liking During Laboratory Alcohol Administration: A Mediated Pathway Analysis.Alcoholism, clinical and experimental research · 2016Trial
- The 10-year stability of three subscale scores of the Self-Report of the Effects of Alcohol measure and their relationship to changes in drinking quantities over the same period.Alcohol, clinical & experimental research · 2026Article
- FACTORS CONTRIBUTING TO THE ESCALATION OF ALCOHOL CONSUMPTION.Neuroscience and biobehavioral reviews · 2022Review
- Subjective Effects of Alcohol Predict Alcohol Choice in Social Drinkers.Alcoholism, clinical and experimental research · 2020Article
- To Infuse or Ingest in Human Laboratory Alcohol Research.Alcoholism, clinical and experimental research · 2020Review
- High-risk social drinkers and heavy drinkers display similar rates of alcohol consumption.Addiction biology · 2020Article
- Association of opioid receptor gene polymorphisms with drinking severity and impulsivity related to alcohol use disorder in a Korean population.CNS neuroscience & therapeutics · 2020Article
- The effect of alcohol use on neuroimaging correlates of cognitive and emotional processing in human adolescence.Neuropsychology · 2019Review
- Does Self-Reported or Behavioral Impulsivity Predict Subjective Response to Low-Dose Alcohol?Alcohol and alcoholism (Oxford, Oxfordshire) · 2019Article
- Does Family History of Alcohol Use Disorder Relate to Differences in Regional Brain Volumes? A Descriptive Review with New Data.Alcoholism, clinical and experimental research · 2018Article
- Implicit Alcohol and Smoking Associations among Young Adult Heavy Drinkers: Associations with Smoking Status and Alcohol-Cigarette Co-Use.Motivation and emotion · 2018Article
- The OPRM1 A118G polymorphism: converging evidence against associations with alcohol sensitivity and consumption.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- A Review of Developmental Considerations in Human Laboratory Alcohol Research.Current addiction reports · 2017Article
- Vulnerability for Alcohol Use Disorder and Rate of Alcohol Consumption.The American journal of psychiatry · 2017Article
- A multilevel structural equation model of within- and between-person associations among subjective responses to alcohol, craving, and laboratory alcohol self-administration.Journal of abnormal psychology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Subjective responses to alcohol are considered candidate endophenotypes for alcohol use disorder and appear to anticipate future consumption. However, prospective studies have been rare, and laboratory research has typically examined subjective responses absent measures of self-administration. This study examined the association of subjective responses with subsequent laboratory self-administration, also evaluating laboratory phenotypes in relation to putative genetic risk factors [family history (FH) of alcohol dependence and OPRM1 genotype] and subsequent heavy drinking. Participants (N = 61, M = 19.89 years, SD = 0.86) completed laboratory sessions involving intravenous alcohol challenge (Session 1) and free-access intravenous self-administration (Session 2), followed by prospective assessments. Multilevel modeling showed that higher reported stimulation and lower sedation during Session 1 independently predicted greater alcohol self-administration during Session 2. Although self-administration did not differ by FH group, participants with the OPRM1 118G allele evidenced steeper breath alcohol concentration (BrAC) trajectories and greater peak BrAC relative to 118A homozygous participants. Prospective analyses supported significant indirect associations between Session 1 subjective responses and 6-month heavy drinking via peak BrAC in Session 2. Additionally, significant indirect associations of FH (via Session 1 stimulation and Session 2 peak BrAC) and OPRM1 (via peak BrAC) with follow-up heavy drinking were observed. These results further support the utility of human laboratory phenotypes in prospective studies of alcohol use disorder risk and highlight the potential role of self-administration phenotypes in longitudinal research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.