Trial reportThe Journal of clinical psychiatry2016
Exaggerated acquisition and resistance to extinction of avoidance behavior in treated heroin-dependent men.
Trial report in The Journal of clinical psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 32 citations in OpenAlex.
- Mindfulness Training vs Recovery Support for Opioid Use, Craving, and Anxiety During Buprenorphine Treatment: A Randomized Clinical Trial.JAMA network open · 2025Trial
- Antenatal Opioid Exposure and Cerebral Cortical Maturation in Newborns.JAMA network open · 2026Article
- Role of preexisting inhibitory control deficits vs. drug use history in mediating insensitivity to aversive consequences in a rat model of polysubstance use.Psychopharmacology · 2022Article
- A systematic review of neural, cognitive, and clinical studies of anger and aggression.Current psychology (New Brunswick, N.J.) · 2022Article
- The role of catecholamines in modulating responses to stress: Sex-specific patterns, implications, and therapeutic potential for post-traumatic stress disorder and opiate withdrawal.The European journal of neuroscience · 2020Review
- Impaired Learning From Errors and Punishments and Maladaptive Avoidance-General Mechanisms Underlying Self-Regulation Disorders?Frontiers in psychiatry · 2020Article
- The role of hippocampal adult neurogenesis in methamphetamine addiction.Brain plasticity (Amsterdam, Netherlands) · 2018Review
- Animal to human translational paradigms relevant for approach avoidance conflict decision making.Behaviour research and therapy · 2017Review
- Sex Differences in Regional Brain Glucose Metabolism Following Opioid Withdrawal and Replacement.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Article
- Greater avoidance behavior in individuals with posttraumatic stress disorder symptoms.Stress (Amsterdam, Netherlands) · 2017Article
- Learning and generalization from reward and punishment in opioid addiction.Behavioural brain research · 2017Article
- Intolerance of uncertainty in opioid dependency - Relationship with trait anxiety and impulsivity.PloS one · 2017Article
- Probabilistic reward- and punishment-based learning in opioid addiction: Experimental and computational data.Behavioural brain research · 2016Article
- The Personality Trait of Intolerance to Uncertainty Affects Behavior in a Novel Computer-Based Conditioned Place Preference Task.Frontiers in psychology · 2016Article
- The Role of Informative and Ambiguous Feedback in Avoidance Behavior: Empirical and Computational Findings.PloS one · 2015Article
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Authors and funding
9 authors at 1 institution.
Funding
Abstract
objectiveAddiction is often conceptualized as a behavioral strategy for avoiding negative experiences. In rodents, opioid intake has been associated with abnormal acquisition and extinction of avoidance behavior. Here, we tested the hypothesis that these findings would generalize to human opioid-dependent subjects.
methodAdults meeting DSM-IV criteria for heroin dependence and treated with opioid medication (n = 27) and healthy controls (n = 26) were recruited between March 2013 and October 2013 and given a computer-based task to assess avoidance behavior. For this task, subjects controlled a spaceship and could either gain points by shooting an enemy spaceship or hide in safe areas to avoid on-screen aversive events. Hiding duration during different periods of the task was used to measure avoidance behavior.
resultsWhile groups did not differ on escape responding (hiding) during the aversive event, heroin-dependent men (but not women) made more avoidance responses during a warning signal that predicted the aversive event (analysis of variance, sex × group interaction, P = .007). Heroin-dependent men were also slower to extinguish the avoidance response when the aversive event no longer followed the warning signal (P = .011). This behavioral pattern resulted in reduced opportunity to obtain reward without reducing risk of punishment. Results suggest that, in male patients, differences in avoidance behavior cannot be easily explained by impaired task performance or by exaggerated motor activity.
conclusionsThis study provides evidence for abnormal acquisition and extinction of avoidance behavior in opioid-dependent patients. Interestingly, data suggest that abnormal avoidance is demonstrated only by male patients. Findings shed light on cognitive and behavioral manifestations of opioid addiction and may facilitate development of therapeutic approaches to help affected individuals.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.