ArticleJournal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research2016
The Role of Dectin-2 for Host Defense Against Disseminated Candidiasis.
Article in Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 58 citations in OpenAlex.
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- Progranulin aggravates lethal Candida albicans sepsis by regulating inflammatory response and antifungal immunity.PLoS pathogens · 2022Article
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- T cell responses to control fungal infection in an immunological memory lens.Frontiers in immunology · 2022Review
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- Pattern recognition receptors as therapeutic targets for bacterial, viral and fungal sepsis.International immunopharmacology · 2021Review
- Local antifungal immunity in the kidney in disseminated candidiasis.Current opinion in microbiology · 2021Review
- Immune Sensing ofJournal of fungi (Basel, Switzerland) · 2021Review
- Dependence on Mincle and Dectin-2 Varies With MultipleFrontiers in microbiology · 2021Article
- The Emerging Role of Mast Cells in Response to Fungal Infection.Frontiers in immunology · 2021Review
- T Cell Antifungal Immunity and the Role of C-Type Lectin Receptors.Trends in immunology · 2020Review
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 3 countries.
Funding
Abstract
Despite the fact that Candida albicans is an important human fungal pathogen and Dectin-2 is a major pattern recognition receptor for fungi, our knowledge regarding the role of Dectin-2 for the host defense against disseminated candidiasis is limited. Dectin-2 deficient (Dectin-2(-/-)) mice were more susceptible to systemic candidiasis, and the susceptibility was mirrored by an elevated fungal load in the kidneys that correlated with the presence of large inflammatory foci. Phagocytosis of Candida by the macrophages lacking the Dectin-2 receptor was moderately decreased, while production of most of the macrophage-derived cytokines from Dectin-2(-/-) mice with systemic candidiasis was decreased. No striking differences among several Candida mutants defective in mannans could be detected between naïve wild-type and Dectin-2(-/-) mice, apart from the β-mannan-deficient bmt1Δ/bmt2Δ/bmt5Δ triple mutant, suggesting that β-mannan may partially mask α-mannan detection, which is the major fungal structure recognized by Dectin-2. Deciphering the mechanisms responsible for host defense against the majority of C. albicans strains represents an important step in understanding the pathophysiology of systemic candidiasis, which might lead to the development of novel immunotherapeutic strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.