ArticleOptometry and vision science : official publication of the American Academy of Optometry2016
Directional Optical Coherence Tomography Reveals Reliable Outer Nuclear Layer Measurements.
Article in Optometry and vision science : official publication of the American Academy of Optometry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Developing Clinically Implementable Approaches for Directional Optical Coherence Tomography.Translational vision science & technology · 2026Article
- Detailed Outer Retinal Assessment in Parkinson's Disease Using Directional OCT.Investigative ophthalmology & visual science · 2026Article
- Keeping an eye on Parkinson's disease: color vision and outer retinal thickness as simple and non-invasive biomarkers.Journal of neurology · 2025Review
- Henle fiber layer thickening and deficits in objective retinal function in participants with a history of multiple traumatic brain injuries.Frontiers in neurology · 2024Article
- Foveal Phase Retardation Correlates With Optically Measured Henle Fiber Layer Thickness.Frontiers in medicine · 2022Article
- Assessing the Interocular Symmetry of Foveal Outer Nuclear Layer Thickness in Achromatopsia.Translational vision science & technology · 2019Article
- Directional optical coherence tomography reveals melanin concentration-dependent scattering properties of retinal pigment epithelium.Journal of biomedical optics · 2019Article
- Outer retinal layers as predictors of visual acuity in retinitis pigmentosa: a cross-sectional study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2019Article
- Suction-induced retinopathy: optical coherence tomography correlations.BMJ case reports · 2018Article
- Assessment of inner and outer retinal layer metrics on the Cirrus HD-OCT Platform in normal eyes.PloS one · 2018Article
- Impacts of age and sex on retinal layer thicknesses measured by spectral domain optical coherence tomography with Spectralis.PloS one · 2018Observational
- Postretinal Structure and Function in Severe Congenital Photoreceptor Blindness Caused by Mutations in the GUCY2D Gene.Investigative ophthalmology & visual science · 2017Article
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Authors and funding
4 authors.
Funding
Abstract
purposeDirectional Optical Coherence Tomography (D-OCT) is a method used to optically segment and identify the outer nuclear layer (ONL) in vivo. The purpose of this study was to determine the repeatability and reproducibility of D-OCT ONL thickness measurements in healthy eyes.
methodsSixteen healthy eyes of sixteen subjects were imaged using the Cirrus SD-OCT. The OCT beam entry position was varied horizontally and vertically through the pupil, and cross-sectional images were obtained at baseline and 1-month follow-up by two observers. Detailed segmentation was performed to quantify the thickness of ONL without the inclusion of overlying Henle Fiber Layer. Inter-observer, intra-observer, and inter-visit variability was evaluated using Bland-Altman and coefficient of variation analysis for each category.
resultsAll 16 eyes were successfully imaged, registered, and segmented. The maximum mean (SD) inter-operator difference was 2.6 (4.8) μm. The maximum mean (SD) intra-operator difference was 2.4 (5.3) μm. There was no statistically significant difference in ONL measurements detected between baseline and follow-up (p > 0.05). The mean (SD) differences measured across visits by one operator varied from -1.6 (3.1) to 1.1 (6.1) μm. The mean (SD) coefficient of variance (CV%) for all sectors with horizontal orientation was 9.1% (2.3%), 10.1% (2.5%), and 8.6% (2.3%) for inter-observer, intra-observer, and inter-visit, respectively. The mean (SD) coefficient of variance (CV%) for all sectors with vertical orientation was 8.3% (1.8%), 6.9% (1.4%), and 8.3% (2.1%) for inter-observer, intra-observer, and inter-visit, respectively. The majority of the variation of paired repeated measurements originated from between-subject variance. The within-subject variance accounted for less than 1% of the total variability.
conclusionsONL thickness measurements can be quantified with good repeatability and reproducibility using D-OCT. Identifying the magnitude of D-OCT variability among normal subjects will allow for improved development of future clinical studies that quantitatively track the progression of macular pathology.
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