ArticlePloS one2016
Anti-Inflammatory and Antinociceptive Properties of Flavonoids from the Fruits of Black Mulberry (Morus nigra L.).
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 122 citations in OpenAlex.
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- Flavonoids and Furanocoumarins Involved in Drug Interactions.Molecules (Basel, Switzerland) · 2025Review
- Polyphenol-rich Morus nigra L. extract mitigates neuroinflammation and cognitive impairment through gut-brain axis modulation in an Alzheimer's disease rat model.Frontiers in pharmacology · 2025Article
- Efficacy of Black Mulberry Mouthwash for Prevention of Chemotherapy-Induced Oral Mucositis: A Double-Blind Randomized Clinical Trial.Frontiers in dentistry · 2025Article
- Black Mulberries (Foods (Basel, Switzerland) · 2024Article
- Optimization of Enzymolysis Modification Conditions of Dietary Fiber from Bayberry Pomace and Its Structural Characteristics and Physicochemical and Functional Properties.Molecules (Basel, Switzerland) · 2024Article
- Chromosome constitution and genetic relationships of Morus spp. revealed by genomic in situ hybridization.BMC plant biology · 2023Article
- Antioxidant and Anti-Inflammatory Activity on LPS-Stimulated RAW 264.7 Macrophage Cells of White Mulberry (Molecules (Basel, Switzerland) · 2023Article
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- Research Progress on Absorption, Metabolism, and Biological Activities of Anthocyanins in Berries: A Review.Antioxidants (Basel, Switzerland) · 2022Review
- Synthesis and Anti-Inflammatory Activity of 1-Methylhydantoin Cinnamoyl Imides.Molecules (Basel, Switzerland) · 2022Article
- The MulberryInternational journal of molecular sciences · 2022Article
- Comparison the Structural, Physicochemical, and Prebiotic Properties of Litchi Pomace Dietary Fibers before and after Modification.Foods (Basel, Switzerland) · 2022Article
- Phytochemical Composition of Different Botanical Parts ofPlants (Basel, Switzerland) · 2022Review
- Bioguided Isolation of Alkaloids and Pharmacological Effects of the Total Alkaloid Fraction fromPlants (Basel, Switzerland) · 2021Article
- Nutritional constituents of mulberry and their potential applications in food and pharmaceuticals: A review.Saudi journal of biological sciences · 2021Review
- Anthocyanins fromPlants (Basel, Switzerland) · 2021Article
- Hierarchical Action of Mulberry miR156 in the Vegetative Phase Transition.International journal of molecular sciences · 2021Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We analyzed the anti-inflammatory and antinociceptive activities of total flavonoids (TF) found in black mulberry fruits. The TF content was 20.9 mg/g (dry weight). Two anthocyanins, cyanidin-3-O-glucoside (8.3 mg/g) and cyanidin-3-O-rutinoside (2.9 mg/g), were identified in the fruits by UPLC. The TF of black mulberry fruits had significant reducing power and radical (OH(-), O2(·-), DPPH and ABTS) scavenging activities that was demonstrated in a dose-response curve. The TF had inhibitory activities on xylene-induced ear edema and carrageenan-induced paw edema in mice. In addition, TF had antinociceptive activities in the two nociceptive phases of formalin test. We used ELISA to detect the pro-inflammatory cytokines IL-1β, TNF-α, IFN-γ, and NO in the serum of mice. These cytokines were significantly inhibited or scavenged by TF (50 and 100 mg/kg). The results demonstrated that TF of black mulberry possess anti-inflammatory and analgesic effects that might correlate to its antioxidant activities and inhibition of pro-inflammatory cytokines.
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