ArticleThe Journal of infection2016
Diversity of Staphylococcus aureus strains colonizing various niches of the human body.
Article in The Journal of infection, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Virulence determinants and multidrug resistance profiles of biofilm-forming Staphylococcus aureus from healthy orthopedic surgical personnel.Antonie van Leeuwenhoek · 2026Article
- High-throughput targeted amplicon screening tool for characterizing intrahost diversity inMicrobial genomics · 2025Article
- Genomic approach to determine sources of neonatal Staphylococcus aureus infection from carriage in the Gambia.BMC infectious diseases · 2024Article
- Genomic Characterization of Methicillin-Susceptible Staphylococcus aureus Carriage in Patients on Home Parenteral Nutrition and Their Caregivers.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024Article
- Changes of Staphylococcus aureus infection in children before and after the COVID-19 pandemic, Henan, China.The Journal of infection · 2023Article
- Quantifying patient- and hospital-level antimicrobial resistance dynamics inmedRxiv : the preprint server for health sciences · 2023Article
- Transmission and Long-Term Colonization Patterns ofInternational journal of environmental research and public health · 2020Article
- Article
- Influence of antibiotic treatment on the detection of S. aureus in whole blood following pathogen enrichment.BMC microbiology · 2019Article
- Isolation of aKorean journal for food science of animal resources · 2018Article
- Bioluminescent murine models of bacterial sepsis and scald wound infections for antimicrobial efficacy testing.PloS one · 2018Article
- Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
objectivesAs individuals may be colonized with multiple strains of Staphylococcus aureus at different body sites, the objectives of this study were to determine whether S. aureus polyclonal colonization exists within one body niche and the optimal sampling sites and culture methodology to capture the diversity of S. aureus strains in community-dwelling individuals.
methodsSwabs were collected from the nares, axillae, and inguinal folds of 3 children with community-associated S. aureus infections and 11 household contacts, all with known S. aureus colonization. S. aureus isolates were recovered from each body niche using 4 culture methods and evaluated for polyclonality using phenotypic and genotypic strain characterization methodologies.
resultsWithin individuals, the mean (range) number of phenotypes and genotypes was 2.4 (1-4) and 3.1 (1-6), respectively. Six (43%) and 10 (71%) participants exhibited phenotypic and genotypic polyclonality within one body niche, respectively. Broth enrichment yielded the highest analytical sensitivity for S. aureus recovery, while direct plating to blood agar yielded the highest genotypic strain diversity.
conclusionsThis study revealed S. aureus polyclonality within a single body niche. Culture methodology and sampling sites influenced the analytical sensitivity of S. aureus colonization detection and the robustness of phenotypic and genotypic strain recovery.
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