ArticleThe American journal of gastroenterology2016
Association Between Affective-Cognitive Symptoms of Depression and Exacerbation of Crohn's Disease.
Article in The American journal of gastroenterology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 3 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Assessment of causal link between psychological factors and symptom exacerbation in inflammatory bowel disease: a systematic review utilising Bradford Hill criteria and meta-analysis of prospective cohort studies.Systematic reviews · 2020Pooled it
- Systematic Review: Components of a Comprehensive Geriatric Assessment in Inflammatory Bowel Disease-A Potentially Promising but Often Neglected Risk Stratification.Journal of Crohn's & colitis · 2019Pooled it
- ACG Clinical Guideline: Management of Crohn's Disease in Adults.The American journal of gastroenterology · 2018Guideline
- Association between gastrointestinal diseases and depression severity among middle-aged and older Chinese women: the mediating effect of sleep duration.BMC psychiatry · 2026Observational
- Association between "Life's Critical 9" health score and the risk of inflammatory bowel disease: a prospective cohort study from the UK biobank.BMC public health · 2026Article
- Shared neurobiological changes in individuals with Crohn's disease and major depressive disorder.Communications medicine · 2025Article
- Psychological Profiles in Ulcerative Colitis and Crohn's Disease: Distinct Emotional and Behavioral Patterns.Biomedicines · 2025Article
- The Spectrum of Psychiatric Comorbidity in Individuals With Inflammatory Bowel Disease.Crohn's & colitis 360 · 2025Article
- Evaluation of inflammatory bowel disease-related sleep disorders based on an interpretable machine learning approach: a multicenter study in China.Therapeutic advances in gastroenterology · 2025Article
- The Comorbidity of Patient-Reported Crohn's Disease Activity and Depression: The Role of Health Behavior Mediators.Crohn's & colitis 360 · 2024Article
- How knowledge time influenced anxiety, depression, stress and quality of life levels in patients suffering from Crohn disease: a cross-sectional multicenter study.Acta bio-medica : Atenei Parmensis · 2023Article
- Because I'm happy - positive affect and its predictive value for future disease activity in patients with inflammatory bowel diseases: a retrospective cohort study.Therapeutic advances in gastroenterology · 2023Article
- Poor Patient-Reported Outcomes and Impaired Work Productivity in Patients With Inflammatory Bowel Disease in Remission.Gastro hep advances · 2022Article
- Venlafaxine as an Adjuvant Therapy for Inflammatory Bowel Disease Patients With Anxious and Depressive Symptoms: A Randomized Controlled Trial.Frontiers in psychiatry · 2022Article
- Impact of the SARS-CoV-2 Delta Variant on the Psychological States and Health-Related Quality of Life in Patients With Crohn's Disease.Frontiers in medicine · 2022Article
- Psychological factors associated with inflammatory bowel disease.British medical bulletin · 2021Review
- The Brain-Gut Axis: Psychological Functioning and Inflammatory Bowel Diseases.Journal of clinical medicine · 2021Review
- Poor Baseline Health of IBD Patients at Presentation to a Surgeon: Results From a Patient-Reported Outcomes Database.Crohn's & colitis 360 · 2021Article
- Interrogating the Gut-Brain Axis in the Context of Inflammatory Bowel Disease: A Translational Approach.Inflammatory bowel diseases · 2020Review
- Does Reverse Causality Underlie the Temporal Relationship Between Depression and Crohn's Disease?Inflammatory bowel diseases · 2020Article
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesThe prevalence of depression is high in patients with Crohn's disease (CD). We examined the influence of affective-cognitive symptoms of depression on the risk of exacerbation of CD.
methodsWe studied 2,144 adult volunteers with a self-reported diagnosis of CD who completed a baseline survey that included demographics, CD status, and an affective-cognitive index of depression. Linear and logistic regression analyses were used to determine whether CD status at 12 months was associated with the baseline measure of depression. Analyses were adjusted for confounders including age, gender, race, baseline disease activity, disease duration, prior hospitalization and surgery, corticosteroid and anti-TNF use, medication adherence, body mass index, current smoking, education, and sleep quality.
resultsDepression was significantly associated with subsequent increases in SCDAI score in both unadjusted (P<0.001) and adjusted (P<0.001) analyses. This association was non-linear, with a shallower slope for lower levels of depression. A 10-point increase in depression t-scores from 55 to 65 was associated with a 18.6-point increase in SCDAI (95% CI 11.5-25.6) and an odds ratio of 1.27 for SCDAI>150 at follow-up (CI: 1.01-1.60). We also found a significant association between depressive symptoms and hospitalization.
conclusionsCognitive-affective depressive symptoms were significantly associated with a risk of exacerbation of CD and hospitalization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.