ArticleHeart & lung : the journal of critical care
The relationship between cardiac hemodynamics and exercise tolerance in cystic fibrosis.
Article in Heart & lung : the journal of critical care. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 13 citations in OpenAlex.
- Physiological responses to cardiopulmonary and field exercise tests in primary ciliary dyskinesia compared with healthy peers.European journal of applied physiology · 2026Article
- Subclinical vascular, hemodynamic and arterial stiffness changes in adults with cystic fibrosis: cross-sectional observational study.Scientific reports · 2024Observational
- Feasibility of the A-STEP for the assessment of exercise capacity in people with cystic fibrosis.Pediatric pulmonology · 2022Article
- Exercise Stroke Volume in Adult Cystic Fibrosis: A Comparison of Acetylene Pulmonary Uptake and Oxygen Pulse.Clinical medicine insights. Circulatory, respiratory and pulmonary medicine · 2018Article
- Subclinical Left Ventricular Dysfunction is Influenced by Genotype Severity in Patients with Cystic Fibrosis.Clinical medicine insights. Circulatory, respiratory and pulmonary medicine · 2018Article
- Effects of high intensity interval training on exercise capacity in people with cystic fibrosis: study protocol for a randomised controlled trial.BMC sports science, medicine & rehabilitation · 2018Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundIndividuals with cystic fibrosis (CF) have reduced pulmonary function and exercise tolerance. Additionally, these individuals may develop abnormal cardiac function. The implications of abnormal cardiac function on exercise tolerance are unclear in CF.
objectiveStudy relationships between exercise cardiac hemodynamics and exercise tolerance in CF.
methods17 CF and 25 controls participated in cardiopulmonary exercise testing to measure exercise duration and peak workload (PW). Cardiac index (QI) was measured using acetylene rebreathe and oxygen uptake (VO2) breath-by-breath. Forced expiratory volume in 1-second (FEV1) was performed at rest.
resultsPeak QI was 6.7 ± 0.5 vs. 9.1 ± 0.3 mL/min/m(2), CF vs. controls, respectively (P < 0.05). Linear regressions between QI (R(2) = 0.63 and 0.51) and exercise duration or PW were stronger than VO2 (R(2) = 0.35 and 0.37) or FEV1 (R(2) = 0.34 and 0.36) in CF, respectively (P < 0.05).
conclusionThese data are clinically relevant suggesting attenuated cardiac function in addition to low airway function relate to exercise tolerance in CF.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.