ArticleTranslational psychiatry2016
BDNF-Val66Met variant and adolescent stress interact to promote susceptibility to anorexic behavior in mice.
Article in Translational psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Genetic polymorphisms and their association with neurobiological and psychological factors in anorexia nervosa: a systematic review.Frontiers in psychology · 2024Pooled it
- Animal Models for Anorexia Nervosa-A Systematic Review.Frontiers in human neuroscience · 2020Pooled it
- Recovery From Anorexia Nervosa: A Concept Analysis.Journal of advanced nursing · 2026Review
- Identification of a neural basis for anorexia nervosa.bioRxiv : the preprint server for biology · 2026Article
- Comprehensive insights into emerging advances in the Neurobiology of anorexia.Journal of advanced research · 2026Review
- Examining the biological causes of eating disorders to inform treatment strategies.Nature reviews. Neuroscience · 2025Review
- Genetics of Anorexia Nervosa: Translation to Future Personalized Therapies.The Psychiatric clinics of North America · 2025Review
- Review
- Repeated stress triggers seeking of a starvation-like state in anxiety-prone female mice.Neuron · 2024Article
- Article
- Establishment of Restraint Stress-induced Anorexia and Social Isolation-induced Anorexia Mouse Models.Bio-protocol · 2023Article
- A Framework for Developing Translationally Relevant Animal Models of Stress-Induced Changes in Eating Behavior.Biological psychiatry · 2022Review
- The BDNF Val66Met Polymorphism Does Not Increase Susceptibility to Activity-Based Anorexia in Rats.Biology · 2022Article
- Activity-based anorexia animal model: a review of the main neurobiological findings.Journal of eating disorders · 2021Review
- Metabolic homeostasis via BDNF and its receptors.Trends in endocrinology and metabolism: TEM · 2021Review
- From Desire to Dread-A Neurocircuitry Based Model for Food Avoidance in Anorexia Nervosa.Journal of clinical medicine · 2021Review
- Caloric Restriction in Group-Housed Mice: Littermate and Sex Influence on Behavioral and Hormonal Data.Frontiers in veterinary science · 2021Article
- Eating Disorders, Heredity and Environmental Activation: Getting Epigenetic Concepts into Practice.Journal of clinical medicine · 2020Review
- A longitudinal, epigenome-wide study of DNA methylation in anorexia nervosa: results in actively ill, partially weight-restored, long-term remitted and non-eating-disordered womenJournal of psychiatry & neuroscience : JPN · 2019Article
- Induced Pluripotent Stem Cells; New Tools for Investigating Molecular Mechanisms in Anorexia Nervosa.Frontiers in nutrition · 2019Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
There is an urgent need to identify therapeutic targets for anorexia nervosa (AN) because current medications do not impact eating behaviors that drive AN's high mortality rate. A major obstacle to developing new treatments is the lack of animal models that recapitulate the pattern of disease onset typically observed in human populations. Here we describe a translational mouse model to study interactions between genetic, psychological and biological risk factors that promote anorexic behavior. We combined several factors that are consistently associated with increased risk of AN-adolescent females, genetic predisposition to anxiety imposed by the BDNF-Val66Met gene variant, social isolation stress and caloric restriction (CR). Approximately 40% of the mice with all of these risk factors will exhibit severe self-imposed dietary restriction, sometimes to the point of death. We systematically varied the risk factors outlined above to explore how they interact to influence anorexic behavior. We found that the Val66Met genotype markedly increases the likelihood and severity of abnormal feeding behavior triggered by CR, but only when CR is imposed in the peri-pubertal period. Incidence of anorexic behavior in our model is dependent on juvenile exposure to social stress and can be extinguished by adolescent handling, but is discordant from anxiety-like behavior. Thus, this study characterized gene × environment interactions during adolescence that could be the underlying driver of abnormal eating behavior in certain AN patients, and represents a promising system to identify possible targets for therapeutic intervention.
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