ArticleScientific reports2016
Novel 3D light microscopic analysis of IUGR placentas points to a morphological correlate of compensated ischemic placental disease in humans.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- A Review of Biomechanics Analysis of the Umbilical-Placenta System With Regards to Diseases.Frontiers in physiology · 2021Pooled it
- Three-Dimensional Architecture of Placental Villous Branching in the Normal Human Placenta: A Scoping Review.Cureus · 2026Review
- Three-dimensional microarchitecture of the human placental villous tree in health and disease.Frontiers in cell and developmental biology · 2025Review
- A flexible generative algorithm for growing in silico placentas.PLoS computational biology · 2024Article
- Article
- Fetal-placental MR angiography at 1.5 T and 3 T.Magnetic resonance imaging · 2023Article
- The Density of Cell Nuclei at the Materno-Fetal Exchange Barrier is Sexually Dimorphic in Normal Placentas, but not in IUGR.Scientific reports · 2019Article
- Placental Morphology Is Associated with Maternal Depressive Symptoms during Pregnancy and Toddler Psychiatric Problems.Scientific reports · 2018Article
- Advances in Human Placental Biomechanics.Computational and structural biotechnology journal · 2018Review
- Whole organ vascular casting and microCT examination of the human placental vascular tree reveals novel alterations associated with pregnancy disease.Scientific reports · 2017Article
- Dynamic modeling of uteroplacental blood flow in IUGR indicates vortices and elevated pressure in the intervillous space - a pilot study.Scientific reports · 2017Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The villous tree of the human placenta is a complex three-dimensional (3D) structure with branches and nodes at the feto-maternal border in the key area of gas and nutrient exchange. Recently we introduced a novel, computer-assisted 3D light microscopic method that enables 3D topological analysis of branching patterns of the human placental villous tree. In the present study we applied this novel method to the 3D architecture of peripheral villous trees of placentas from patients with intrauterine growth retardation (IUGR placentas), a severe obstetric syndrome. We found that the mean branching angle of branches in terminal positions of the villous trees was significantly different statistically between IUGR placentas and clinically normal placentas. Furthermore, the mean tortuosity of branches of villous trees in directly preterminal positions was significantly different statistically between IUGR placentas and clinically normal placentas. We show that these differences can be interpreted as consequences of morphological adaptation of villous trees between IUGR placentas and clinically normal placentas, and may have important consequences for the understanding of the morphological correlates of the efficiency of the placental villous tree and their influence on fetal development.
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