ArticleScientific reports2016
Identification of four new gene members of the KAP6 gene family in sheep.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 32 citations in OpenAlex.
- Wool: From Properties and Structure to Genetic Insights and Sheep Improvement Strategies.Animals : an open access journal from MDPI · 2025Review
- Detection of a Second KAP22 Family Member in Sheep and Analysis of Its Genetic Variation and Associations with Selected Wool Fibre Traits.Animals : an open access journal from MDPI · 2025Article
- Characterisation of Four New Genes in the Ovine KAP19 Family.International journal of molecular sciences · 2025Article
- The Identification of a New GeneGenes · 2025Article
- Skin Appendage Proteins of Tetrapods: Building Blocks of Claws, Feathers, Hair and Other Cornified Epithelial Structures.Animals : an open access journal from MDPI · 2025Review
- Genetics of Wool and Cashmere Fibre: Progress, Challenges, and Future Research.Animals : an open access journal from MDPI · 2024Article
- Exploring Variation in OvineAnimals : an open access journal from MDPI · 2024Article
- Sequence Variation in CaprineAnimals : an open access journal from MDPI · 2022Article
- The Complexity of the Ovine and Caprine Keratin-Associated Protein Genes.International journal of molecular sciences · 2021Review
- A highly polymorphic caprine keratin-associated protein gene identified and its effect on cashmere traits.Journal of animal science · 2021Article
- Variation in a Newly Identified CaprineGenes · 2021Article
- Variation in the KRTAP6-3 gene and its association with wool characteristics in Pakistani sheep breeds and breed-crosses.Tropical animal health and production · 2020Article
- Polymorphism in the ovine keratin-associated protein gene KRTAP7-1 and its association with wool characteristics.Journal of animal science · 2020Article
- Article
- Identification of the Ovine Keratin-Associated Protein 21-1 Gene and Its Association with Variation in Wool Traits.Animals : an open access journal from MDPI · 2019Article
- Identification of Ovine KRTAP28-1 and Its Association with Wool Fibre Diameter.Animals : an open access journal from MDPI · 2019Article
- Associations between variation in the ovine high glycine-tyrosine keratin-associated protein gene KRTAP20-1 and wool traits.Journal of animal science · 2019Article
- Variation in the Caprine KAP24-1 Gene Affects Cashmere Fibre Diameter.Animals : an open access journal from MDPI · 2019Article
- Variation inArchives animal breeding · 2019Article
- Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
KAP6 is a high glycine-tyrosine keratin-associated protein (HGT-KAP) family. This family is thought to contain multiple genes. In this study, we used a KRTAP6 coding sequence to search the Ovine Genome (v3.1) and identified five homologous regions (R1-R5). All these regions contained an open reading frame, and they were either identical to, or highly similar to, sheep skin Expressed Sequence Tags (ESTs). Phylogenetic analysis revealed that R1-R5 were clustered with KAP6 sequences from different species and formed a group distinct to other HGT-KAPs. R1 was very similar to the characterised KRTAP6-1 sequence, but the remaining genes appeared to be new. PCR primers were designed to amplify and confirm the presence of these new genes. Amplicons were obtained for all of the 96 sheep investigated. Six, five, three and six PCR-SSCP patterns representing six, five, three and six DNA sequences were observed for KRTAP6-2 to KRTAP6-5 respectively. KRTAP6-2 and KRTAP6-4 had five and three SNPs respectively. Three SNPs and a 45-bp insertion/deletion were detected for KRTAP6-3, and five SNPs and an 18-bp insertion/deletion were identified for KRTAP6-5. Allele frequencies for these KAP6 genes differed between Merino and Romney sheep.
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Registered trials
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