ArticleScientific reports2016
Epigenetic regulation of NKG2D ligands is involved in exacerbated atherosclerosis development in Sirt6 heterozygous mice.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Targeting epigenetics and non-coding RNAs in atherosclerosis: from mechanisms to therapeutics.Pharmacology & therapeutics · 2019Pooled it
- Review
- Integrative multi-omics analysis of macrophage polarization-related genes in atherosclerosis development.Clinical epigenetics · 2026Article
- Atrial Cardiomyopathy-associated Arrhythmia and the Impact of Sirtuin Signaling Pathway: A Narrative Review.Current vascular pharmacology · 2025Review
- NADHeliyon · 2023Review
- Sirtuin 2 deficiency aggravates ageing-induced vascular remodelling in humans and mice.European heart journal · 2023Article
- SIRT6 is an epigenetic repressor of thoracic aortic aneurysms via inhibiting inflammation and senescence.Signal transduction and targeted therapy · 2023Article
- SIRT6 in Aging, Metabolism, Inflammation and Cardiovascular Diseases.Aging and disease · 2022Review
- SIRT6 in Vascular Diseases, from Bench to Bedside.Aging and disease · 2022Article
- SIRT6 promotes angiogenesis and hemorrhage of carotid plaque via regulating HIF-1α and reactive oxygen species.Cell death & disease · 2021Article
- SIRT6 in Senescence and Aging-Related Cardiovascular Diseases.Frontiers in cell and developmental biology · 2021Review
- Potential therapeutic effects of cyanidin-3-O-glucoside on rheumatoid arthritis by relieving inhibition of CD38+ NK cells on Treg cell differentiation.Arthritis research & therapy · 2019Article
- Epigenetics of metabolic syndrome.Physiological genomics · 2018Review
- SIRT1 and SIRT6 Signaling Pathways in Cardiovascular Disease Protection.Antioxidants & redox signaling · 2018Review
- Sirtuins and Insulin Resistance.Frontiers in endocrinology · 2018Review
- Icariin, an Anti-atherosclerotic Drug from Chinese Medicinal Herb Horny Goat Weed.Frontiers in pharmacology · 2017Review
- SIRT1 deacetylates the cardiac transcription factor Nkx2.5 and inhibits its transcriptional activity.Scientific reports · 2016Article
- Sirtuins in Cardiovascular Health and Diseases.Trends in endocrinology and metabolism: TEM · 2016Article
- Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sirt6 is a member of the class III histone deacetylase family which is associated with aging and longevity. Sirt6 deficient mice show an aging-like phenotype, while male transgenic mice of Sirt6 show increased longevity. Sirt6 acts as a tumor suppressor and deficiency of Sirt6 leads to cardiac hypertrophy and heart failure. Whether Sirt6 is involved in atherosclerosis development, the major cause of cardiovascular diseases, is unknown. We found that the expression of Sirt6 is lower in human atherosclerotic plaques than that in controls. When Sirt6(+/-)ApoE(-/-) and ApoE(-/-) mice are fed with high fat diet for 16 weeks, Sirt6(+/-)ApoE(-/-) mice show increased plaque fromation and exhibit feature of plaque instability. Furthermore, Sirt6 downregulation increases expression of NKG2D ligands, which leads to increased cytokine expression. Blocking NKG2D ligand almost completely blocks this effect. Mechanistically, Sirt6 binds to promoters of NKG2D ligand genes and regulates the H3K9 and H3K56 acetylation levels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.