ArticleJournal of psychiatry & neuroscience : JPN2016
Partially restored resting-state functional connectivity in women recovered from anorexia nervosa.
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Article in Journal of psychiatry & neuroscience : JPN, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25citing papers in PubMed
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25 citing papers in PubMed, 44 citations in OpenAlex.
- Functional connectivity and treatment response in obesity and eating disorders: Current evidence and empirical data.Reviews in endocrine & metabolic disorders · 2026Review
- Brain Connectivity and Machine Learning Approaches to assess the underlying neurobiology and prediction accuracy of anorexia nervosa: A replication study.Psychiatry research. Neuroimaging · 2026Article
- Disrupted Salience Network and Its Deteriorated Interaction With the Central Executive Network in Anorexia Nervosa: A Multicenter Study.Biological psychiatry global open science · 2026Article
- Recovery From Anorexia Nervosa: A Concept Analysis.Journal of advanced nursing · 2026Review
- Annual Research Review: Neural mechanisms of eating disorders in youth - from current theory and findings to future directions.Journal of child psychology and psychiatry, and allied disciplines · 2026Review
- Resting-state functional brain connectivity in female adolescents with first-onset anorexia nervosa.NeuroImage. Clinical · 2025Article
- Disrupted longitudinal restoration of brain connectivity during weight normalization in severe anorexia nervosa.Translational psychiatry · 2023Article
- Longitudinal study in adolescent anorexia nervosa: evaluation of cortico-striatal and default mode network resting-state brain circuits.European child & adolescent psychiatry · 2023Article
- Article
- Ketamine as a Novel Psychopharmacotherapy for Eating Disorders: Evidence and Future Directions.Brain sciences · 2022Review
- Altered functional connectivity in adolescent anorexia nervosa is related to age and cortical thickness.BMC psychiatry · 2021Article
- Cortical thinning and associated connectivity changes in patients with anorexia nervosa.Translational psychiatry · 2021Article
- The Role of the Human Hypothalamus in Food Intake Networks: An MRI Perspective.Frontiers in nutrition · 2021Review
- Evaluation of spontaneous regional brain activity in weight-recovered anorexia nervosa.Translational psychiatry · 2020Article
- Study protocol of comprehensive risk evaluation for anorexia nervosa in twins (CREAT): a study of discordant monozygotic twins with anorexia nervosa.BMC psychiatry · 2020Article
- Peripheral serotonin transporter DNA methylation is linked to increased salience network connectivity in females with anorexia nervosaJournal of psychiatry & neuroscience : JPN · 2020Article
- Intact value-based decision-making during intertemporal choice in women with remitted anorexia nervosa? An fMRI studyJournal of psychiatry & neuroscience : JPN · 2020Article
- The Neurobiology of Eating Disorders.Child and adolescent psychiatric clinics of North America · 2019Review
- Resting-state connectivity within and across neural circuits in anorexia nervosa.Brain and behavior · 2019Article
- Recent advances in understanding anorexia nervosa.F1000Research · 2019Review
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Authors and funding
12 authors at 5 institutions in 2 countries.
Ilka BoehmFrom the Eating Disorder Services and Research Center, Department of Child and Adolescent Psychiatry, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany (Boehm, Geisler, Tam, King, Ritschel, Seidel, Bernardoni, Roessner, Ehrlich); the MGH/MIT/HMS Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA (Ehrlich); the Harvard Medical School, Department of Psychiatry, Massachusetts General Hospital, Boston, MA (Ehrlich); the Department of Psychotherapy and Psychosomatic Medicine, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany (Murr); the Department of Psychology, Technische Universität Dresden, Dresden, Germany (Goschke); the The Mind Research Network, Albuquerque, New Mexico (Calhoun); and the Department of ECE, the University of New Mexico, Albuquerque, New Mexico (Calhoun).
Daniel GeislerFrom the Eating Disorder Services and Research Center, Department of Child and Adolescent Psychiatry, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany (Boehm, Geisler, Tam, King, Ritschel, Seidel, Bernardoni, Roessner, Ehrlich); the MGH/MIT/HMS Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA (Ehrlich); the Harvard Medical School, Department of Psychiatry, Massachusetts General Hospital, Boston, MA (Ehrlich); the Department of Psychotherapy and Psychosomatic Medicine, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany (Murr); the Department of Psychology, Technische Universität Dresden, Dresden, Germany (Goschke); the The Mind Research Network, Albuquerque, New Mexico (Calhoun); and the Department of ECE, the University of New Mexico, Albuquerque, New Mexico (Calhoun).
Friederike TamFrom the Eating Disorder Services and Research Center, Department of Child and Adolescent Psychiatry, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany (Boehm, Geisler, Tam, King, Ritschel, Seidel, Bernardoni, Roessner, Ehrlich); the MGH/MIT/HMS Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA (Ehrlich); the Harvard Medical School, Department of Psychiatry, Massachusetts General Hospital, Boston, MA (Ehrlich); the Department of Psychotherapy and Psychosomatic Medicine, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany (Murr); the Department of Psychology, Technische Universität Dresden, Dresden, Germany (Goschke); the The Mind Research Network, Albuquerque, New Mexico (Calhoun); and the Department of ECE, the University of New Mexico, Albuquerque, New Mexico (Calhoun).
Joseph A KingFrom the Eating Disorder Services and Research Center, Department of Child and Adolescent Psychiatry, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany (Boehm, Geisler, Tam, King, Ritschel, Seidel, Bernardoni, Roessner, Ehrlich); the MGH/MIT/HMS Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA (Ehrlich); the Harvard Medical School, Department of Psychiatry, Massachusetts General Hospital, Boston, MA (Ehrlich); the Department of Psychotherapy and Psychosomatic Medicine, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany (Murr); the Department of Psychology, Technische Universität Dresden, Dresden, Germany (Goschke); the The Mind Research Network, Albuquerque, New Mexico (Calhoun); and the Department of ECE, the University of New Mexico, Albuquerque, New Mexico (Calhoun).
Franziska RitschelFrom the Eating Disorder Services and Research Center, Department of Child and Adolescent Psychiatry, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany (Boehm, Geisler, Tam, King, Ritschel, Seidel, Bernardoni, Roessner, Ehrlich); the MGH/MIT/HMS Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA (Ehrlich); the Harvard Medical School, Department of Psychiatry, Massachusetts General Hospital, Boston, MA (Ehrlich); the Department of Psychotherapy and Psychosomatic Medicine, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany (Murr); the Department of Psychology, Technische Universität Dresden, Dresden, Germany (Goschke); the The Mind Research Network, Albuquerque, New Mexico (Calhoun); and the Department of ECE, the University of New Mexico, Albuquerque, New Mexico (Calhoun).
Maria SeidelFrom the Eating Disorder Services and Research Center, Department of Child and Adolescent Psychiatry, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany (Boehm, Geisler, Tam, King, Ritschel, Seidel, Bernardoni, Roessner, Ehrlich); the MGH/MIT/HMS Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA (Ehrlich); the Harvard Medical School, Department of Psychiatry, Massachusetts General Hospital, Boston, MA (Ehrlich); the Department of Psychotherapy and Psychosomatic Medicine, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany (Murr); the Department of Psychology, Technische Universität Dresden, Dresden, Germany (Goschke); the The Mind Research Network, Albuquerque, New Mexico (Calhoun); and the Department of ECE, the University of New Mexico, Albuquerque, New Mexico (Calhoun).
Fabio BernardoniFrom the Eating Disorder Services and Research Center, Department of Child and Adolescent Psychiatry, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany (Boehm, Geisler, Tam, King, Ritschel, Seidel, Bernardoni, Roessner, Ehrlich); the MGH/MIT/HMS Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA (Ehrlich); the Harvard Medical School, Department of Psychiatry, Massachusetts General Hospital, Boston, MA (Ehrlich); the Department of Psychotherapy and Psychosomatic Medicine, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany (Murr); the Department of Psychology, Technische Universität Dresden, Dresden, Germany (Goschke); the The Mind Research Network, Albuquerque, New Mexico (Calhoun); and the Department of ECE, the University of New Mexico, Albuquerque, New Mexico (Calhoun).
Julia MurrFrom the Eating Disorder Services and Research Center, Department of Child and Adolescent Psychiatry, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany (Boehm, Geisler, Tam, King, Ritschel, Seidel, Bernardoni, Roessner, Ehrlich); the MGH/MIT/HMS Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA (Ehrlich); the Harvard Medical School, Department of Psychiatry, Massachusetts General Hospital, Boston, MA (Ehrlich); the Department of Psychotherapy and Psychosomatic Medicine, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany (Murr); the Department of Psychology, Technische Universität Dresden, Dresden, Germany (Goschke); the The Mind Research Network, Albuquerque, New Mexico (Calhoun); and the Department of ECE, the University of New Mexico, Albuquerque, New Mexico (Calhoun).
Thomas GoschkeFrom the Eating Disorder Services and Research Center, Department of Child and Adolescent Psychiatry, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany (Boehm, Geisler, Tam, King, Ritschel, Seidel, Bernardoni, Roessner, Ehrlich); the MGH/MIT/HMS Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA (Ehrlich); the Harvard Medical School, Department of Psychiatry, Massachusetts General Hospital, Boston, MA (Ehrlich); the Department of Psychotherapy and Psychosomatic Medicine, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany (Murr); the Department of Psychology, Technische Universität Dresden, Dresden, Germany (Goschke); the The Mind Research Network, Albuquerque, New Mexico (Calhoun); and the Department of ECE, the University of New Mexico, Albuquerque, New Mexico (Calhoun).
Vince D CalhounFrom the Eating Disorder Services and Research Center, Department of Child and Adolescent Psychiatry, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany (Boehm, Geisler, Tam, King, Ritschel, Seidel, Bernardoni, Roessner, Ehrlich); the MGH/MIT/HMS Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA (Ehrlich); the Harvard Medical School, Department of Psychiatry, Massachusetts General Hospital, Boston, MA (Ehrlich); the Department of Psychotherapy and Psychosomatic Medicine, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany (Murr); the Department of Psychology, Technische Universität Dresden, Dresden, Germany (Goschke); the The Mind Research Network, Albuquerque, New Mexico (Calhoun); and the Department of ECE, the University of New Mexico, Albuquerque, New Mexico (Calhoun).
Veit RoessnerFrom the Eating Disorder Services and Research Center, Department of Child and Adolescent Psychiatry, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany (Boehm, Geisler, Tam, King, Ritschel, Seidel, Bernardoni, Roessner, Ehrlich); the MGH/MIT/HMS Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA (Ehrlich); the Harvard Medical School, Department of Psychiatry, Massachusetts General Hospital, Boston, MA (Ehrlich); the Department of Psychotherapy and Psychosomatic Medicine, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany (Murr); the Department of Psychology, Technische Universität Dresden, Dresden, Germany (Goschke); the The Mind Research Network, Albuquerque, New Mexico (Calhoun); and the Department of ECE, the University of New Mexico, Albuquerque, New Mexico (Calhoun).
Stefan EhrlichFrom the Eating Disorder Services and Research Center, Department of Child and Adolescent Psychiatry, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany (Boehm, Geisler, Tam, King, Ritschel, Seidel, Bernardoni, Roessner, Ehrlich); the MGH/MIT/HMS Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA (Ehrlich); the Harvard Medical School, Department of Psychiatry, Massachusetts General Hospital, Boston, MA (Ehrlich); the Department of Psychotherapy and Psychosomatic Medicine, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany (Murr); the Department of Psychology, Technische Universität Dresden, Dresden, Germany (Goschke); the The Mind Research Network, Albuquerque, New Mexico (Calhoun); and the Department of ECE, the University of New Mexico, Albuquerque, New Mexico (Calhoun).
Massachusetts General Hospital · USMind Research Network · USHarvard University · USTU Dresden · DEAthinoula A. Martinos Center for Biomedical Imaging · US
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe have previously shown increased resting-state functional connectivity (rsFC) in the frontoparietal network (FPN) and the default mode network (DMN) in patients with acute anorexia nervosa. Based on these findings we investigated within-network rsFC in patients recovered from anorexia nervosa to examine whether these abnormalities are a state or trait marker of the disease. To extend the understanding of functional connectivity in patients with anorexia nervosa, we also estimated rsFC between large-scale networks.
methodsGirls and women recovered from anorexia nervosa and pair-wise, age- and sex-matched healthy controls underwent a resting-state fMRI scan. Using independent component analyses (ICA), we isolated the FPN, DMN and salience network. We used standard comparisons as well as a hypothesis-based approach to test the findings of our previous rsFC study in this recovered cohort. Temporal correlations between network time-course pairs were computed to investigate functional network connectivity (FNC).
resultsThirty-one patients recovered from anorexia nervosa and 31 controls participated in our study. Standard group comparisons revealed reduced rsFC between the dorsolateral prefrontal cortex (dlPFC) and the FPN in the recovered group. Using a hypothesis-based approach we extended the previous finding of increased rsFC between the angular gyrus and the FPN in patients recovered from anorexia nervosa. No group differences in FNC were revealed. LIMITATIONS: The study design did not allow us to conclude that the difference found in rsFC constitutes a scar effect of the disease.
conclusionThis study suggests that some abnormal rsFC patterns found in patients recovered from anorexia nervosa normalize after long-term weight restoration, while distorted rsFC in the FPN, a network that has been associated with cognitive control, may constitute a trait marker of the disorder.
Indexed as
Anorexia NervosaBrainBrain MappingCross-Sectional StudiesFemaleHumansMagnetic Resonance ImagingNeural PathwaysRestYoung Adult
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