ArticlePloS one2016
Resveratrol Antagonizes Antimicrobial Lethality and Stimulates Recovery of Bacterial Mutants.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 49 citations in OpenAlex.
- Biological Activity of Stilbenoids Against Fungal, Parasitic, and Viral Pathogens.Molecules (Basel, Switzerland) · 2026Review
- Molecular Docking and Structure-Activity Relationship Study of Polyphenols with Antibacterial and Antibiotic-Modulating Properties.Microorganisms · 2026Article
- Suppression of virulence factors of uropathogenic Escherichia coli by Trans-resveratrol and design of nanoemulgel.BMC microbiology · 2024Article
- Antimicrobial Activity of 2-(Piperazin-1-yl)naphtho[2,3-d]thiazole-4,9-dione against Staphylococcus Strains.Molecules (Basel, Switzerland) · 2024Article
- Resveratrol attenuates advanced glycation end product-induced senescence and inflammation in human gingival fibroblasts.Journal of dental sciences · 2024Article
- Baicalein Inhibits theInfection and drug resistance · 2023Article
- Resveratrol biosynthesis, optimization, induction, bio-transformation and bio-degradation in mycoendophytes.Frontiers in microbiology · 2022Review
- Genome-Wide Identification of Resveratrol Intrinsic Resistance Determinants inAntibiotics (Basel, Switzerland) · 2021Article
- A Comprehensive Study on the Antimicrobial Properties of Resveratrol as an Alternative Therapy.Evidence-based complementary and alternative medicine : eCAM · 2021Review
- anti-HCoV: A web resource to collect natural compounds against human coronaviruses.Trends in food science & technology · 2020Review
- Effect of resveratrol and quercetin on the susceptibility of Escherichia coli to antibiotics.World journal of microbiology & biotechnology · 2020Article
- Total alkaloids ofChinese herbal medicines · 2020Article
- Post-stress bacterial cell death mediated by reactive oxygen species.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Resveratrol: A Double-Edged Sword in Health Benefits.Biomedicines · 2018Review
- Suppression of Reactive Oxygen Species Accumulation Accounts for Paradoxical Bacterial Survival at High Quinolone Concentration.Antimicrobial agents and chemotherapy · 2018Article
- Resveratrol Attenuates the Cytotoxicity Induced by Amyloid-βNeurochemical research · 2018Article
- Resveratrol-Mediated Attenuation ofFrontiers in microbiology · 2018Article
- Resveratrol-Potential Antibacterial Agent against Foodborne Pathogens.Frontiers in pharmacology · 2018Review
- Article
- Sucralose Increases Antimicrobial Resistance and Stimulates Recovery of Escherichia coli Mutants.Current microbiology · 2017Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
Reactive oxygen species (ROS; superoxide, peroxide, and hydroxyl radical) are thought to contribute to the rapid bactericidal activity of diverse antimicrobial agents. The possibility has been raised that consumption of antioxidants in food may interfere with the lethal action of antimicrobials. Whether nutritional supplements containing antioxidant activity are also likely to interfere with antimicrobial lethality is unknown. To examine this possibility, resveratrol, a popular antioxidant dietary supplement, was added to cultures of Escherichia coli and Staphylococcus aureus that were then treated with antimicrobial and assayed for bacterial survival and the recovery of mutants resistant to an unrelated antimicrobial, rifampicin. Resveratrol, at concentrations likely to be present during human consumption, caused a 2- to 3-fold reduction in killing during a 2-hr treatment with moxifloxacin or kanamycin. At higher, but still subinhibitory concentrations, resveratrol reduced antimicrobial lethality by more than 3 orders of magnitude. Resveratrol also reduced the increase in reactive oxygen species (ROS) characteristic of treatment with quinolone (oxolinic acid). These data support the general idea that the lethal activity of some antimicrobials involves ROS. Surprisingly, subinhibitory concentrations of resveratrol promoted (2- to 6-fold) the recovery of rifampicin-resistant mutants arising from the action of ciprofloxacin, kanamycin, or daptomycin. This result is consistent with resveratrol reducing ROS to sublethal levels that are still mutagenic, while the absence of resveratrol allows ROS levels to high enough to kill mutagenized cells. Suppression of antimicrobial lethality and promotion of mutant recovery by resveratrol suggests that the antioxidant may contribute to the emergence of resistance to several antimicrobials, especially if new derivatives and/or formulations of resveratrol markedly increase bioavailability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.