ArticleMedical science monitor : international medical journal of experimental and clinical research2016
White and Gray Matter Volume Changes and Correlation with Visual Evoked Potential in Patients with Optic Neuritis: A Voxel-Based Morphometry Study.
Article in Medical science monitor : international medical journal of experimental and clinical research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 30 citations in OpenAlex.
- Brain activity in different brain areas of patients with diabetic vitreous hemorrhage according to voxel-based morphometry.International journal of ophthalmology · 2025Article
- VEP Score of a Left Eye Had Predictive Values for Achieving NEDA-3 over Ten Years in Patients with Multiple Sclerosis.Sensors (Basel, Switzerland) · 2022Article
- Gray matter volume alterations in patients with strabismus and amblyopia: voxel-based morphometry study.Scientific reports · 2022Article
- Brain Activity in Different Brain Areas of Patients With Dry Eye During the Female Climacteric Period According to Voxel-Based Morphometry.Frontiers in neurology · 2022Article
- The Predictive Potential of Altered Voxel-Based Morphometry in Severely Obese Patients With Meibomian Gland Dysfunction.Frontiers in neuroscience · 2022Article
- Article
- White Matter Hyperintensities of Bilateral Lenticular Putamen in Patients with Proliferative Diabetic Retinopathy: A Voxel-based Morphometric Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
- Morphological and microstructural brain changes in thyroid-associated ophthalmopathy: a combined voxel-based morphometry and diffusion tensor imaging study.Journal of endocrinological investigation · 2020Article
- Altered intrinsic functional connectivity of the primary visual cortex in patients with retinal vein occlusion: a resting-state fMRI study.Quantitative imaging in medicine and surgery · 2020Article
- Central network changes in patients with advanced monocular blindness: A voxel-based morphometric study.Brain and behavior · 2019Article
- Gray Matter Volume Changes in Patients With Acute Eye Pain: A Voxel-Based Morphometry Study.Translational vision science & technology · 2019Article
- Altered whole-brain gray matter volume in high myopia patients: a voxel-based morphometry study.Neuroreport · 2018Article
- Altered Brain Structure and Functional Connectivity of Primary Visual Cortex in Optic Neuritis.Frontiers in human neuroscience · 2018Article
- Brain Correlates of Single Trial Visual Evoked Potentials in Migraine: More Than Meets the Eye.Frontiers in neurology · 2018Article
- The atrophy of white and gray matter volume in patients with comitant strabismus: Evidence from a voxel-based morphometry study.Molecular medicine reports · 2017Article
- Structure-function relationships in the visual system in multiple sclerosis: an MEG and OCT study.Annals of clinical and translational neurology · 2017Article
- Altered regional homogeneity in patients with unilateral acute open-globe injury: a resting-state functional MRI study.Neuropsychiatric disease and treatment · 2016Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this study was to investigate potential morphological alterations of gray and white matter in patients with optic neuritis (ON) and their relationship with behavioral performance, using voxel-based morphometry (VBM). MATERIAL/
methodsTwelve (4 males, 8 females) patients with ON and 12 (4 males, 8 females) age-, sex-, and education-matched healthy controls (HCs) underwent magnetic resonance imaging (MRI). Imaging data were analyzed using two-sample t tests to identify group differences in gray and white matter volume (GMV, WMV). Correlation analysis was used to explore relationships between observed GMV and WMV of different areas and visual evoked potential (VEP) in ON.
resultsCompared with HCs, ON patients had: significantly decreased GMV in the left postcentral gyrus, left inferior frontal gyrus, left anterior cingulate, left and right middle frontal gyrus, and right inferior parietal lobule; decreased WMV in the left middle frontal gyrus, right superior frontal gyrus, left precentral gyrus and right inferior parietal lobule; and increased WMV in the left fusiform gyrus and left inferior parietal lobule. VEP latency of the right eye in ON correlated positively with WMV signal value of the left fusiform gyrus (r=0.726, p=0.008), and negatively with GMV signal value of the right inferior parietal lobule (r=-0.611, p=0.035). Duration of ON correlated negatively with WMV signal value of the right superior frontal gyrus (r=-0.662, p=0.019), while best-corrected visual acuity (VA) of the right eye correlated negatively with WMV signal value of the left middle frontal gyrus (r=-0.704, p=0.011).
conclusionsThese results suggest significant brain involvement in ON, which may reflect the underlying pathologic mechanism. Correlational results demonstrate that VEP in ON is closely associated with WMV and GMV atrophy in many brain regions.
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