ArticleBiochimica et biophysica acta2016
Computational modelling of placental amino acid transfer as an integrated system.
Article in Biochimica et biophysica acta, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 33 citations in OpenAlex.
- A genetically small fetus impairs placental adaptations near term.Disease models & mechanisms · 2024Article
- Regulation of placental amino acid transport in health and disease.Acta physiologica (Oxford, England) · 2024Review
- Convergently evolved placental villi show multiscale structural adaptations to differential placental invasiveness.Biology letters · 2024Article
- Article
- Regulation of maternal-fetal metabolic communication.Cellular and molecular life sciences : CMLS · 2021Review
- Engineering and women's health: a slow start, but gaining momentum.Interface focus · 2019Review
- A systems perspective on placental amino acid transport.The Journal of physiology · 2018Review
- Analytical model of the feto-placental vascular system: consideration of placental oxygen transport.Royal Society open science · 2018Article
- Transfer and Metabolism of Cortisol by the Isolated Perfused Human Placenta.The Journal of clinical endocrinology and metabolism · 2018Article
- Functional Polarity of Microvascular Brain Endothelial Cells Supported by Neurovascular Unit Computational Model of Large Neutral Amino Acid Homeostasis.Frontiers in physiology · 2018Article
- Article
- Treating the dysfunctional placenta.The Journal of endocrinology · 2017Review
- The influence of placental metabolism on fatty acid transfer to the fetus.Journal of lipid research · 2017Article
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
Abstract
Placental amino acid transfer is essential for fetal development and its impairment is associated with poor fetal growth. Amino acid transfer is mediated by a broad array of specific plasma membrane transporters with overlapping substrate specificity. However, it is not fully understood how these different transporters work together to mediate net flux across the placenta. Therefore the aim of this study was to develop a new computational model to describe how human placental amino acid transfer functions as an integrated system. Amino acid transfer from mother to fetus requires transport across the two plasma membranes of the placental syncytiotrophoblast, each of which contains a distinct complement of transporter proteins. A compartmental modelling approach was combined with a carrier based modelling framework to represent the kinetics of the individual accumulative, exchange and facilitative classes of transporters on each plasma membrane. The model successfully captured the principal features of transplacental transfer. Modelling results clearly demonstrate how modulating transporter activity and conditions such as phenylketonuria, can increase the transfer of certain groups of amino acids, but that this comes at the cost of decreasing the transfer of others, which has implications for developing clinical treatment options in the placenta and other transporting epithelia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.