ArticlePhilosophical transactions. Series A, Mathematical, physical, and engineering sciences2016
Alterations in the coupling functions between cortical and cardio-respiratory oscillations due to anaesthesia with propofol and sevoflurane.
Article in Philosophical transactions. Series A, Mathematical, physical, and engineering sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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36 citing papers in PubMed, 79 citations in OpenAlex.
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- Central autonomic network alterations in male endurance athletes.Scientific reports · 2022Article
- Integrating psychosocial variables and societal diversity in epidemic models for predicting COVID-19 transmission dynamics.PLOS digital health · 2022Article
- Normalizing the brain connectome for communication through synchronization.Network neuroscience (Cambridge, Mass.) · 2022Article
- Resting State EEG Directed Functional Connectivity Unveils Changes in Motor Network Organization in Subacute Stroke Patients After Rehabilitation.Frontiers in physiology · 2022Article
- Directional couplings between the respiration and parasympathetic control of the heart rate during sleep and wakefulness in healthy subjects at different ages.Frontiers in network physiology · 2022Article
- Propofol Versus Sevoflurane General Anaesthesia for Selective Impairment of Attention Networks After Gynaecological Surgery in Middle-Aged Women: A Randomised Controlled Trial.Frontiers in psychiatry · 2022Article
- Identifying Cognitive Impairment in Elderly Using Coupling Functions Between Cerebral Oxyhemoglobin and Arterial Blood Pressure.Frontiers in aging neuroscience · 2022Article
- Detection of Cross-Frequency Coupling Between Brain Areas: An Extension of Phase Linearity Measurement.Frontiers in neuroscience · 2022Article
- Evaluation of Anesthetic Specific EEG Dynamics during State Transitions between Loss and Return of Responsiveness.Brain sciences · 2021Article
- Mild poikilocapnic hypoxia increases very low frequency haemoglobin oxygenation oscillations in prefrontal cortex.Biological research · 2021Article
- A Bridge between the Breath and the Brain: Synchronization of Respiration, a Pupillometric Marker of the Locus Coeruleus, and an EEG Marker of Attentional Control State.Brain sciences · 2021Article
- Towards new concepts for a biological neuroscience of consciousness.Cognitive neurodynamics · 2021Article
- Article
- Coupling between Blood Pressure and Subarachnoid Space Width Oscillations during Slow Breathing.Entropy (Basel, Switzerland) · 2021Article
- Multiscale Entropy Analysis: Application to Cardio-Respiratory Coupling.Entropy (Basel, Switzerland) · 2020Article
- Directed Connectivity Analysis of the Neuro-Cardio- and Respiratory Systems Reveals Novel Biomarkers of Susceptibility to SUDEP.IEEE open journal of engineering in medicine and biology · 2020Article
- Experimental and Computational Study on Motor Control and Recovery After Stroke: Toward a Constructive Loop Between Experimental and Virtual Embodied Neuroscience.Frontiers in systems neuroscience · 2020Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The precise mechanisms underlying general anaesthesia pose important and still open questions. To address them, we have studied anaesthesia induced by the widely used (intravenous) propofol and (inhalational) sevoflurane anaesthetics, computing cross-frequency coupling functions between neuronal, cardiac and respiratory oscillations in order to determine their mutual interactions. The phase domain coupling function reveals the form of the function defining the mechanism of an interaction, as well as its coupling strength. Using a method based on dynamical Bayesian inference, we have thus identified and analysed the coupling functions for six relationships. By quantitative assessment of the forms and strengths of the couplings, we have revealed how these relationships are altered by anaesthesia, also showing that some of them are differently affected by propofol and sevoflurane. These findings, together with the novel coupling function analysis, offer a new direction in the assessment of general anaesthesia and neurophysiological interactions, in general.
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