ArticlePhilosophical transactions. Series A, Mathematical, physical, and engineering sciences2016
Central- and autonomic nervous system coupling in schizophrenia.
Article in Philosophical transactions. Series A, Mathematical, physical, and engineering sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Brain-body dysconnectivity: deficient autonomic regulation of cortical function in first-episode schizophrenia.Psychological medicine · 2025Article
- A new directionality index based on high-resolution joint symbolic dynamics to assess information transfer in multivariate networks.Frontiers in neuroscience · 2025Article
- Heart rate variability in schizophrenia: A comparative analysis before and after electroconvulsive therapy.PCN reports : psychiatry and clinical neurosciences · 2024Article
- The contribution of granger causality analysis to our understanding of cardiovascular homeostasis: from cardiovascular and respiratory interactions to central autonomic network control.Frontiers in network physiology · 2024Review
- A Complex Combination Therapy for a Complex Disease-Neuroimaging Evidence for the Effect of Music Therapy in Schizophrenia.Frontiers in psychiatry · 2022Review
- Functional brain-heart interplay extends to the multifractal domain.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2021Article
- A Potential Interface between the Kynurenine Pathway and Autonomic Imbalance in Schizophrenia.International journal of molecular sciences · 2021Review
- Effect of music listening on P300 event-related potential in patients with schizophrenia: A pilot study.Schizophrenia research · 2020Article
- Altered Autonomic Function in Individuals at Clinical High Risk for Psychosis.Frontiers in psychiatry · 2020Article
- Altered Causal Coupling Pathways within the Central-Autonomic-Network in Patients Suffering from Schizophrenia.Entropy (Basel, Switzerland) · 2019Article
- Risk Stratification in Idiopathic Dilated Cardiomyopathy Patients Using Cardiovascular Coupling Analysis.Frontiers in physiology · 2019Article
- Alterations in Maternal-Fetal Heart Rate Coupling Strength and Directions in Abnormal Fetuses.Frontiers in physiology · 2019Article
- Exercise-Induced Changes of Multimodal Interactions Within the Autonomic Nervous Network.Frontiers in physiology · 2019Article
- Uncovering brain-heart information through advanced signal and image processing.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2016Article
Corrections and comments
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Authors and funding
4 authors.
Funding
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Abstract
The autonomic nervous system (ANS) dysfunction has been well described in schizophrenia (SZ), a severe mental disorder. Nevertheless, the coupling between the ANS and central brain activity has been not addressed until now in SZ. The interactions between the central nervous system (CNS) and ANS need to be considered as a feedback-feed-forward system that supports flexible and adaptive responses to specific demands. For the first time, to the best of our knowledge, this study investigates central-autonomic couplings (CAC) studying heart rate, blood pressure and electroencephalogram in paranoid schizophrenic patients, comparing them with age-gender-matched healthy subjects (CO). The emphasis is to determine how these couplings are composed by the different regulatory aspects of the CNS-ANS. We found that CAC were bidirectional, and that the causal influence of central activity towards systolic blood pressure was more strongly pronounced than such causal influence towards heart rate in paranoid schizophrenic patients when compared with CO. In paranoid schizophrenic patients, the central activity was a much stronger variable, being more random and having fewer rhythmic oscillatory components. This study provides a more in-depth understanding of the interplay of neuronal and autonomic regulatory processes in SZ and most likely greater insights into the complex relationship between psychotic stages and autonomic activity.
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