Evidence map›Paper›PMID 27044982›Full record

Observational studyEuropace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology2016

Entropy of cardiac repolarization predicts ventricular arrhythmias and mortality in patients receiving an implantable cardioverter-defibrillator for primary prevention of sudden death.

Deeptankar DeMazumder, Worawan B Limpitikul, Miguel Dorante, Swati Dey, Bhasha Mukhopadhyay, Yiyi Zhang, J Randall Moorman, Alan Cheng, Ronald D Berger, Eliseo Guallar and 2 more

Open access · bronzeAbstract readMulticenter StudyObservational Study
In one paragraph

Observational study in Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Deeptankar DeMazumderDivision of Cardiology, Johns Hopkins University School of Medicine, 720 North Rutland Avenue, Ross 844, Baltimore, MD 21205, USA deep@jhmi.edu gtomasel@jhmi.edu.
Worawan B LimpitikulDivision of Cardiology, Johns Hopkins University School of Medicine, 720 North Rutland Avenue, Ross 844, Baltimore, MD 21205, USA.
Miguel DoranteDivision of Cardiology, Johns Hopkins University School of Medicine, 720 North Rutland Avenue, Ross 844, Baltimore, MD 21205, USA.
Swati DeyDivision of Cardiology, Johns Hopkins University School of Medicine, 720 North Rutland Avenue, Ross 844, Baltimore, MD 21205, USA.
Bhasha MukhopadhyayDivision of Cardiology, Johns Hopkins University School of Medicine, 720 North Rutland Avenue, Ross 844, Baltimore, MD 21205, USA.
Yiyi ZhangDepartment of Epidemiology and Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
J Randall MoormanDivision of Cardiology, University of Virginia, Charlottesville, VA, USA.
Alan ChengDivision of Cardiology, Johns Hopkins University School of Medicine, 720 North Rutland Avenue, Ross 844, Baltimore, MD 21205, USA.
Ronald D BergerDivision of Cardiology, Johns Hopkins University School of Medicine, 720 North Rutland Avenue, Ross 844, Baltimore, MD 21205, USA.
Eliseo GuallarDepartment of Epidemiology and Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Steven R JonesDivision of Cardiology, Johns Hopkins University School of Medicine, 720 North Rutland Avenue, Ross 844, Baltimore, MD 21205, USA.
Gordon F TomaselliDivision of Cardiology, Johns Hopkins University School of Medicine, 720 North Rutland Avenue, Ross 844, Baltimore, MD 21205, USA deep@jhmi.edu gtomasel@jhmi.edu.
Johns Hopkins University · USJohns Hopkins Medicine · USUniversity of Virginia · US

Funding

Autonomic remodeling and modulation therapy in heart failure and sudden deathK99HL130662 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI DEMAZUMDER, DEEPTANKAR · 2016 to 2016
$172k
NHLBI NIH HHS K99 HL130662
6 · The paper itself

Abstract

aimsThe need for a readily available, inexpensive, non-invasive method for improved risk stratification of heart failure (HF) patients is paramount. Prior studies have proposed that distinct fluctuation patterns underlying the variability of physiological signals have unique prognostic value. We tested this hypothesis in an extensively phenotyped cohort of HF patients using EntropyX METHODS AND

resultsIn a prospective, multicentre, observational study of 852 patients in sinus rhythm undergoing clinically indicated primary prevention implantable cardioverter-defibrillator (ICD) implantation (2003-10), exposures included demographics, history, physical examination, medications, laboratory results, serum biomarkers, ejection fraction, conventional electrocardiographic (ECG) analyses of heart rate and QT variability, and EntropyX

conclusionsEntropyX

Indexed as

Defibrillators, ImplantableAgedArrhythmias, CardiacDeath, Sudden, CardiacElectrocardiographyEntropyFemaleHeart FailureHeart RateHumansMaleMiddle AgedMyocardial IschemiaPrimary PreventionProportional Hazards ModelsProspective StudiesChaos theoryHeart failureHeart rate variabilityNon-linear dynamicsQT variabilityRisk predictionSudden cardiac death

Identifiers

PMID27044982
PMCPMC5291192
OpenAlexW2318155855

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.