ArticleJournal of cell science2016
Two classes of short intraflagellar transport train with different 3D structures are present in Chlamydomonas flagella.
Article in Journal of cell science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Article
- Distribution and bulk flow analyses of the intraflagellar transport (IFT) motor kinesin-2 support an "on-demand" model for Chlamydomonas ciliary length control.Cytoskeleton (Hoboken, N.J.) · 2024Article
- Review
- Anti-Virulence Strategy of Novel Dehydroabietic Acid Derivatives: Design, Synthesis, and Antibacterial Evaluation.International journal of molecular sciences · 2023Article
- The flagellar length control system: exploring the physical biology of organelle size.Physical biology · 2023Review
- Flagellar energy costs across the tree of life.eLife · 2022Article
- Male infertility-associated Ccdc108 regulates multiciliogenesis via the intraflagellar transport machinery.EMBO reports · 2022Article
- Article
- Compartmentalization of Photoreceptor Sensory Cilia.Frontiers in cell and developmental biology · 2021Review
- Intraflagellar transport trains and motors: Insights from structure.Seminars in cell & developmental biology · 2020Review
- Speed and Diffusion of Kinesin-2 Are Competing Limiting Factors in Flagellar Length-Control Model.Biophysical journal · 2020Article
- Testing the role of intraflagellar transport in flagellar length control using length-altering mutants ofPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- Setting the dynein motor in motion: New insights from electron tomography.The Journal of biological chemistry · 2019Review
- BBS4 is required for intraflagellar transport coordination and basal body number in mammalian olfactory cilia.Journal of cell science · 2019Article
- Composition, structure and function of the eukaryotic flagellum distal tip.Essays in biochemistry · 2018Review
- Bidirectional intraflagellar transport is restricted to two sets of microtubule doublets in the trypanosome flagellum.The Journal of cell biology · 2018Article
- The cryo-EM structure of intraflagellar transport trains reveals how dynein is inactivated to ensure unidirectional anterograde movement in cilia.Nature cell biology · 2018Article
- Review
- Super-Resolution Imaging Reveals TCTN2 Depletion-Induced IFT88 Lumen Leakage and Ciliary Weakening.Biophysical journal · 2018Article
- Crystal structure of intraflagellar transport protein 80 reveals a homo-dimer required for ciliogenesis.eLife · 2018Article
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Authors and funding
9 authors.
Funding
Abstract
Intraflagellar transport (IFT) is responsible for the bidirectional trafficking of molecular components required for the elongation and maintenance of eukaryotic cilia and flagella. Cargo is transported by IFT 'trains', linear rows of multiprotein particles moved by molecular motors along the axonemal doublets. We have previously described two structurally distinct categories of 'long' and 'short' trains. Here, we analyse the relative number of these trains throughout flagellar regeneration and show that long trains are most abundant at the beginning of flagellar growth whereas short trains gradually increase in number as flagella elongate. These observations are incompatible with the previous hypothesis that short trains are derived solely from the reorganization of long trains at the flagellar tip. We demonstrate with electron tomography the existence of two distinct ultrastructural organizations for the short trains, we name these 'narrow' and 'wide', and provide the first 3D model of the narrow short trains. These trains are characterized by tri-lobed units, which repeat longitudinally every 16 nm and contact protofilament 7 of the B-tubule. Functional implications of the new structural evidence are discussed.
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Registered trials
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